Protein Alignment Tie and Fyn

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_006256584.1
• Gene: Fyn / 25150
• RGDID: 2641
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 458
• Identity: 116/458 - (25%)
• Similarity: 175/458 - (38%)
• Gaps: 145/458 - (31%)

  Fly   786 DDDEDEVDHQHHQHMQHHQN-----------HQNHQNHQHHQAMPMSQASQRDAN---------H 830
            |.|:.:.||..|..::...|           ....|..||:        |:|.|.         |
  Rat   229 DWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY--------SERAAGLCCRLVVPCH 285

  Fly   831 NRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR-AC 894
            .......|.:....:..:..|.:::|...||.|.||:||       .|.:.....||:||:: ..
  Rat   286 KGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVW-------MGTWNGNTKVAIKTLKPGT 343

  Fly   895 SAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV 959
            .:..|..:||.||:|| .|..:|.|. |.|..||..::.||..:|.||..|:........||
  Rat   344 MSPESFLEEAQIMKKL-KHDKLVQLY-AVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLP--- 403

  Fly   960 PGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE 1024
                        .|...|..:|.||.||.....:||||.:.|:|:.:..:|||.|||::
  Rat   404 ------------NLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLA------ 450

  Fly  1025 RMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDT 1089
            |:.::.|..|..              |:::
  Rat   451 RLIEDNEYTARQ--------------GAKF----------------------------------- 466

  Fly  1090 IGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPD 1154
                   ||:|.|||:..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|..
  Rat   467 -------PIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP 524

  Fly  1155 LPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            .|::.....:.||..||.|:|..||:|                      :|:  .||.||
  Rat   525 CPQDCPISLHELMIHCWKKDPEERPTF----------------------EYL--QGFLED----- 560

  Fly  1220 VYF 1222
             ||
  Rat   561 -YF 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	94/329 (29%)
		PTKc	860..1187	CDD:270623	93/327 (28%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	12/61 (20%)
		PTKc_Fyn	299..572	CDD:270655	102/380 (27%)
		Pkinase_Tyr	309..558	CDD:285015	96/358 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010