DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Yes1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_006245737.1	Gene:	Yes1 / 24884	RGDID:	3977	Length:	541	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	160/699 - (22%)
Similarity:	248/699 - (35%)	Gaps:	226/699 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 TTEKPSTTTSTS---------TTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTS 580
            |.|.|:...:||         |..||   |::|..:.|.. |.:.||...:|..||....:||.|
  Rat    17 TPENPTEPVNTSAGHYGVEHATAATT---SSTKGASANFN-SLSMTPFGGSSGVTPFGGASSSFS 77

  Fly   581 TTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTD 645
              |:|::...            :|...:|..:.:.|..     ...|.|.......:.|..:.|:
  Rat    78 --VVPSSYPT------------SLTGGVTIFVALYDYE-----ARTTEDLSFKKGERFQIINNTE 123

  Fly   646 SSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEV-----YIGIVESSSSASPA 705
            ......|                  |..|......|....||::.:     |.|      .....
  Rat   124 GDWWEAR------------------SIATGKNGYIPSNYVAPADSIQAEEWYFG------KMGRK 164

  Fly   706 DISSTVI--ANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCIT 768
            |....::  .|:|.:                                |::|........:.:.|.
  Rat   165 DAERLLLNPGNQRGI--------------------------------FLVRESETTKGAYSLSIR 197

  Fly   769 DQQPIS-------PVKKVD-------SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMP 819
            |...:.       .::|:|       ::.|.|..:..|        :|:..|.:...|:.....|
  Rat   198 DWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLV--------KHYTEHADGLCHKLTTVCP 254

  Fly   820 MSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATR 884
            ..:...:              .||.:..:..|.::||:..||:|.||:||       .|.:..|.
  Rat   255 TVKPQTQ--------------GLAKDAWEIPRESLRLEVKLGQGCFGEVW-------MGTWNGTT 298

  Fly   885 IVAVKTIR-ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAA 948
            .||:||:: ......:...||.||:|| .|..:|.|. |.|..||..::.|:..:|.||..|:..
  Rat   299 KVAIKTLKPGTMMPEAFLQEAQIMKKL-RHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEG 361

  Fly   949 RSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKIC 1013
            ......||               .|...|..||.||.||.....:||||.|.|:|:..|.:|||.
  Rat   362 DGKYLKLP---------------QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIA 411

  Fly  1014 DFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPH 1078
            |||::      |:.::.|..|..              |:::
  Rat   412 DFGLA------RLIEDNEYTARQ--------------GAKF------------------------ 432

  Fly  1079 GEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREV 1143
                              ||:|.|||:..|..||.::|:|:|||:..|:.|.|..||..:..|||
  Rat   433 ------------------PIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREV 479

  Fly  1144 IRRVPQGLRPDLPK---ESRHEFYNLMSRCWHKEPHMRPSF--AQSRLE 1187
            :.:|.:|.|...|:   ||.||..||   ||.|:|..||:|  .||.||
  Rat   480 LEQVERGYRMPCPQGCPESLHELMNL---CWKKDPDERPTFEYIQSFLE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	100/334 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	100/332 (30%)
Yes1	XP_006245737.1	SH3_Yes	92..149	CDD:212940	12/79 (15%)
		SH2_Src_family	152..251	CDD:199827	17/144 (12%)
		PTKc_Yes	262..540	CDD:270654	107/353 (30%)
		Pkinase_Tyr	275..524	CDD:285015	102/337 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010