Protein Alignment Tie and Ret

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_036775.2
• Gene: Ret / 24716
• RGDID: 3556
• Length: 1115
• Species: Rattus norvegicus
• Alignment Length: 1114
• Identity: 248/1114 - (22%)
• Similarity: 394/1114 - (35%)
• Gaps: 341/1114 - (30%)

  Fly   293 HGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPIRPGG 357
            :|::.....:|..: ||..||       |:.....|::....|:..              ||.||
  Rat    73 YGVYRTRLHENDWI-HIDSGT-------GLLYLNQSLDHSSWEQLS--------------IRNGG 115

  Fly   358 ---LTI---------KAAEGDDDHPRVLEV--SVAQSTTPTITTTST----TPAP-----VSSTR 399
               ||:         ...||:...|....|  |....|.|..::...    ||..     :...|
  Rat   116 FPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKARDLCTPETGVSFRIRENR 180

  Fly   400 PTASTRR-PLTPVE--RSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDS 461
            |..:..: .:.||:  ......||.:.|...:|....|.....:     ||:        .|...
  Rat   181 PPGTFYQFRMLPVQFLCPNISVKYKLLEGDGLPFRCDPDCLEVS-----TRW--------ALDRE 232

  Fly   462 IQD--LKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTT 524
            :|:  :.:.|..||.|...:  :||:.|...            |...:.::.||......|::..
  Rat   233 LQEKYVLEAECAVAGPGANK--EKVAVSFPV------------TVYDEDDSPPTFSGGVGTASAV 283

  Fly   525 TTEKPSTTTSTST-----TTTTPVPSTSKRTTTNAPLSTTN-TPTTTTSSTTPSTTTTSSTSTTV 583
            ...|....|..:|     ....|......|..|:..||..: ...|.....||:.|...|.:.:|
  Rat   284 VEFKRKEGTVVATLQVFDADVVPASGELVRRYTSTLLSGDSWAQQTFRVEHTPNETLVQSNNNSV 348

  Fly   584 IPTTTKANSIIEKDKELIRALGPALTREINIDDAN--NLIVFCNNTS-------------DCGVT 633
            ..|......:              |.|.::|.::.  .|:|..|::.             :..|.
  Rat   349 RATMHNYKLV--------------LNRSLSISESRVLQLVVLVNDSDFQGPGSGVLFLHFNVSVL 399

  Fly   634 PRTQTQP-SHTTDSSPKILRTTVL-------------TSIRSTVHPRPTSTS---TTTSTTTTAP 681
            |.|...| :::...:.:..|...:             .||:..:.|..|:.|   ..|||..|
  Rat   400 PVTLNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTNCSALGVVTSTEDT-- 462

  Fly   682 PAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGV-------IP 739
                  |..:|:...|:.......::..||:|.:|    :.||....:||:...|.       .|
  Rat   463 ------SGTLYVNDTEALRRPECTELQYTVVATDR----QTRRQTQASLVVTVEGTYIAEEVGCP 517

  Fly   740 LAAII---------------------------LYLVRNFVI-----------RRRAKQSEVFDVC 766
            .:..:                           ..:.|||..           ...|.:|...::|
  Rat   518 KSCAVNKRRPECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINIC 582

  Fly   767 ITD--QQPI---------SPVKK--------VDSKYQVDDDEDEVD------------------- 793
            ..|  :.||         ..:|.        .|.|....:.||...
  Rat   583 PQDCLRGPIVGGHERGERQGIKAGYGICNCFPDEKKCFCEPEDSQGPLCDELCRTVITAAVLFSF 647

  Fly   794 -----------HQHHQHMQHHQNHQNHQNH-QHHQAMPMSQAS------QRDANHNRYGNNDDKT 840
                       |::|:|............. :..|..|:|.:|      ..|:..|:...:..|.
  Rat   648 IISVLLSTFCIHRYHKHAHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSMENQVSVDSFKI 712

  Fly   841 SLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD--- 902
            ....:: :|.|.|:.|...||||.||:|.||.|..|.|..|.| .||||.::..::|..|:|
  Rat   713 PEDPKW-EFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYT-TVAVKMLKENASQSELRDLLS 775

  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSL-- 965
            |.|::::: :|.:|:.|.|||.:..|.:||:|||..|.|...||.:|   .|.||.|..|.|.
  Rat   776 EFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSR---KIGPAYVSSGGSRNS 836

  Fly   966 --------APLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLD 1022
                    ..|:...|..||..|:.||:|:|..::|||||||||:|:......||.|||:|.|:.
  Rat   837 SSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 901

  Fly  1023 AERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGH 1087
            .|                           ..|:                         |||
  Rat   902 EE---------------------------DSYV-------------------------KKS---- 910

  Fly  1088 DTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLR 1152
                 :..:|::|||.|||..|::||::|:|:||::||||.|||..||..:....:...:..|.|
  Rat   911 -----KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 970

  Fly  1153 PDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS-------- 1209
            .:.|.....|.|.||.:||.:||..||.||    :|::.|.|.:   ..:.||:|::
  Rat   971 MERPDNCSEEMYRLMLQCWKQEPDKRPVFA----DISKDLEKMM---VKSRDYLDLAASTPSDSL 1028

  Fly  1210 ----GFSED 1214
                |.||:
  Rat  1029 LYDDGLSEE 1037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/341 (34%)
		PTKc	860..1187	CDD:270623	115/339 (34%)
Ret	NP_036775.2	Cadherin	173..248	CDD:278457	16/87 (18%)
		PTKc_RET	724..1013	CDD:173631	120/361 (33%)
		Pkinase_Tyr	725..1006	CDD:285015	117/350 (33%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900