Protein Alignment Tie and FGFR4

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_002002.3
• Gene: FGFR4 / 2264
• HGNCID: 3691
• Length: 802
• Species: Homo sapiens
• Alignment Length: 380
• Identity: 117/380 - (30%)
• Similarity: 173/380 - (45%)
• Gaps: 102/380 - (26%)

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-------ATRIVAVKTIRACSAQVSLKD--- 902
            :|.|..:.|...||||.||||.:|||      ||       ....||||.::..::...|.|
Human   461 EFPRDRLVLGKPLGEGCFGQVVRAEA------FGMDPARPDQASTVAVKMLKDNASDKDLADLVS 519

  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAP 967
            |..:|:.:|.|:|::.|||.|.:..|..:|:|.|.:|.|...|||.|          |.|..|:|
Human   520 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR----------PPGPDLSP 574

  Fly   968 LSPRT---------LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDA 1023
            ..||:         |...|..:|.||:|:..|:.:||||||||||:..:.:.||.|||::
Human   575 DGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLA----- 634

  Fly  1024 ERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHD 1088
                             ...|...:                               .||:.:|.
Human   635 -----------------RGVHHIDY-------------------------------YKKTSNGR- 650

  Fly  1089 TIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRP 1153
                   ||::|||||:|...::|.::|:|:|||:||||.|||.:||..:...|:...:.:|.|.
Human   651 -------LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 708

  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDV 1208
            |.|.....|.|.||..|||..|..||:|.|    :..:|.|.:  .:.:.:|:|:
Human   709 DRPPHCPPELYGLMRECWHAAPSQRPTFKQ----LVEALDKVL--LAVSEEYLDL 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	110/347 (32%)
FGFR4	NP_002002.3	Ig_3	36..104	CDD:464046
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..148
		IgI_2_FGFR	147..241	CDD:409443
		Ig strand A	147..150	CDD:409443
		Ig strand A'	158..163	CDD:409443
		Ig strand B	167..175	CDD:409443
		Ig strand C	181..186	CDD:409443
		Ig strand C'	189..191	CDD:409443
		Ig strand D	200..203	CDD:409443
		Ig strand E	207..212	CDD:409443
		Ig strand F	221..228	CDD:409443
		Ig strand G	231..241	CDD:409443
		Ig	249..351	CDD:472250
		Ig strand B	267..271	CDD:409444
		Ig strand C	280..284	CDD:409444
		Ig strand E	316..320	CDD:409444
		Ig strand F	330..335	CDD:409444
		Ig strand G	343..346	CDD:409444
		Protein Kinases, catalytic domain	454..767	CDD:473864	117/380 (31%)