DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and FGFR2

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	432	Identity:	125/432 - (28%)
Similarity:	195/432 - (45%)	Gaps:	110/432 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 HQHHQAMPM----SQASQRDANHN--------RYGNNDDKTSLA--SEFH-------DFERSNIR 855
            |:..:.:|:    |..|....|.|        |..:..|...||  ||:.       :|.|..:.
Human   436 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT 500

  Fly   856 LKSLLGEGNFGQVWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMRKLGSHQNV 916
            |...||||.||||..|||..:........: ||||.::..:.:..|.|   |..:|:.:|.|:|:
Human   501 LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 565

  Fly   917 VTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLA---------PLSPRT 972
            :.|||||.:..|..:|:|||.:|.|...|||.|          |.|...:         .::.:.
Human   566 INLLGACTQDGPLYVIVEYASKGNLREYLRARR----------PPGMEYSYDINRVPEEQMTFKD 620

  Fly   973 LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAAND 1037
            |......:|.||||:|.::.:||||||||||:..|.:.||.|||::.|::
Human   621 LVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN--------------- 670

  Fly  1038 LMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMA 1102
                     ..|:                             .||:.:|.        ||::|||
Human   671 ---------NIDY-----------------------------YKKTTNGR--------LPVKWMA 689

  Fly  1103 PESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLM 1167
            ||:|...::|.::|:|:||:::|||.|||.:||..:...|:.:.:.:|.|.|.|....:|.|.:|
Human   690 PEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 754

  Fly  1168 SRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            ..|||..|..||:|.|...::.|.|....::     :|:|:|
Human   755 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNE-----EYLDLS 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	105/341 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	105/339 (31%)
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174
		IG_like	66..143	CDD:214653
		Ig2_FGFR	183..267	CDD:143265
		IG_like	282..376	CDD:214653
		Ig3_FGFR	290..377	CDD:143175
		PTKc_FGFR2	474..786	CDD:270679	115/387 (30%)
		Pkinase_Tyr	499..775	CDD:285015	106/346 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810