Protein Alignment Tie and Yes1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001192061.1
• Gene: Yes1 / 22612
• MGIID: 99147
• Length: 541
• Species: Mus musculus
• Alignment Length: 680
• Identity: 156/680 - (22%)
• Similarity: 237/680 - (34%)
• Gaps: 224/680 - (32%)

  Fly   561 TPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCN 625
            ||...|...:||.:.......||.||::...:.:..:...:...|
Mouse    17 TPENLTEPVSPSASHYGVEHATVAPTSSTKGASVNFNSLSMTPFG-------------------- 61

  Fly   626 NTSDCGVTPRTQTQPSHTTDSS--PKIL---------------RTTVLTS---------IRSTVH 664
              ...||||......|.:..||  |..|               |||...|         |.:|..
Mouse    62 --GSSGVTPFGGASSSFSVVSSSYPTGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEG 124

  Fly   665 PRPTSTSTTTSTTTTAP-----PAVTAPSNEVYIGIVESSSSASPADISSTVI--ANERDLNMEM 722
            ....:.|..|..:...|     ||.:..:.|.|.|      .....|....::  .|:|.:
Mouse   125 DWWEARSIATGKSGYIPSNYVVPADSIQAEEWYFG------KMGRKDAERLLLNPGNQRGI---- 179

  Fly   723 RRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPIS-------PVKKVD 780
                                        |::|........:.:.|.|...:.       .::|:|
Mouse   180 ----------------------------FLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLD 216

  Fly   781 -------SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDD 838
                   ::.|.|..:..|        :|:..|.:...|:.....|..:...:
Mouse   217 NGGYYITTRAQFDTLQKLV--------KHYTEHADGLCHKLTTVCPTVKPQTQ------------ 261

  Fly   839 KTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR-ACSAQVSLKD 902
              .||.:..:..|.::||:..||:|.||:||       .|.:..|..||:||:: ......:...
Mouse   262 --GLAKDAWEIPRESLRLEVKLGQGCFGEVW-------MGTWNGTTKVAIKTLKPGTMMPEAFLQ 317

  Fly   903 EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAP 967
            ||.||:|| .|..:|.|. |.|..||..::.|:..:|.||..|:........||
Mouse   318 EAQIMKKL-RHDKLVPLY-AVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLP----------- 369

  Fly   968 LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEK 1032
                .|...|..||.||.||.....:||||.|.|:|:..|.:|||.|||::      |:.::.|.
Mouse   370 ----QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLA------RLIEDNEY 424

  Fly  1033 NAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALP 1097
            .|..              |:::                                          |
Mouse   425 TARQ--------------GAKF------------------------------------------P 433

  Fly  1098 IRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPK---ES 1159
            |:|.|||:..|..||.::|:|:|||:..|:.|.|..||..:..|||:.:|.:|.|...|:   ||
Mouse   434 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 498

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSF--AQSRLE 1187
            .||..||   ||.|:|..||:|  .||.||
Mouse   499 LHELMNL---CWKKDPDERPTFEYIQSFLE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	100/334 (30%)
		PTKc	860..1187	CDD:270623	100/332 (30%)
Yes1	NP_001192061.1	SH3_Yes	92..149	CDD:212940	10/56 (18%)
		SH2_Src_family	152..251	CDD:199827	18/144 (13%)
		PTKc_Yes	262..540	CDD:270654	107/353 (30%)
		Pkinase_Tyr	275..524	CDD:285015	102/337 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010