DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and FGFR3

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_006713931.1	Gene:	FGFR3 / 2261	HGNCID:	3690	Length:	811	Species:	Homo sapiens

Alignment Length:	384	Identity:	117/384 - (30%)
Similarity:	179/384 - (46%)	Gaps:	88/384 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMR 908
            :..|:.:.|...||||.||||..|||..:.....|..: ||||.::..:....|.|   |..:|:
Human   470 ELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMK 534

  Fly   909 KLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLA------- 966
            .:|.|:|::.|||||.:..|..:::|||.:|.|...|||.|          |.|...:
Human   535 MIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR----------PPGLDYSFDTCKPP 589

  Fly   967 --PLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
              .|:.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:
Human   590 EEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-------- 646

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                       ||...:                                  ||:.:|.
Human   647 -----------HNLDYY----------------------------------KKTTNGR------- 659

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES 1159
             ||::|||||:|...::|.::|:|:||::||||.|||.:||..:...|:.:.:.:|.|.|.|...
Human   660 -LPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANC 723

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHG 1218
            .|:.|.:|..|||..|..||:|.|    :...|.:.:...|...:|:|:|...|....|
Human   724 THDLYMIMRECWHAAPSQRPTFKQ----LVEDLDRVLTVTSTDQEYLDLSAPFEQYSPG 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	108/341 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	108/339 (32%)
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706
		IG	54..125	CDD:214652
		Ig2_FGFR	161..245	CDD:143265
		IG_like	171..245	CDD:214653
		IG_like	260..355	CDD:214653
		Ig3_FGFR	268..356	CDD:143175
		PKc_like	463..797	CDD:304357	117/384 (30%)
		Pkinase_Tyr	476..752	CDD:285015	109/350 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810