DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and FGFR1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	869	Identity:	197/869 - (22%)
Similarity:	321/869 - (36%)	Gaps:	254/869 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   430 TAAPPP-----AAPPAPPVS--------------RTRYVGSGRPTAGLSDSIQDLKQTESEVAKP 475
            ||.|.|     |.|...||.              |.|.....:....|.|.:|..:...:.:...
Human    53 TARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGE 117

  Fly   476 VVRRVVQKVSPSSSTPLIITVLSAEEETT---VGQTEALPTDESTTTTSTTTTTEKPSTTTSTST 537
            .| .|...|...|.....:|...:..:||   |..::|||:.|.......:::.||.:..|..:.
Human   118 EV-EVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNR 181

  Fly   538 TTTTPV---PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTT------------------------T 575
            ....|.   |...::.....|.:.| ......||.||:.|                        |
Human   182 MPVAPYWTSPEKMEKKLHAVPAAKT-VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 245

  Fly   576 TSSTSTTVIPTTTKAN------------------SIIEKD--KELIRALGPALTREINIDDANNL 620
            .|....:|:| :.|.|                  .::|:.  :.:::|..|| .:.:.:  .:|:
Human   246 WSIIMDSVVP-SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA-NKTVAL--GSNV 306

  Fly   621 IVFCNNTSDCGVTPRTQTQ-PSHT--------TDSSP--KILRTTVLTSI---RSTVHPRPTSTS 671
            ...|...||    |:...| ..|.        .|:.|  :||:|..:.:.   ...:|.|..|..
Human   307 EFMCKVYSD----PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 367

  Fly   672 TTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVG 736
            .....|..|..::....:..::.::|:                     :|.|         .||.
Human   368 DAGEYTCLAGNSIGLSHHSAWLTVLEA---------------------LEER---------PAVM 402

  Fly   737 VIPL-AAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHM 800
            ..|| ..||:|....|:|.           |:.....:..:|....|...
Human   403 TSPLYLEIIIYCTGAFLIS-----------CMVGSVIVYKMKSGTKKSDF--------------- 441

  Fly   801 QHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGN-----------NDDKTSLASEFHDFE---- 850
                 |.....|:..:::|:.:.....|:.:...|           :...|.:.:...::|
Human   442 -----HSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPED 501

  Fly   851 ------RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI--VAVKTIRACSAQVSLKD---EA 904
                  |..:.|...||||.||||..|||..|... ...|:  ||||.:::.:.:..|.|   |.
Human   502 PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD-KPNRVTKVAVKMLKSDATEKDLSDLISEM 565

  Fly   905 NIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV-----PGGRS 964
            .:|:.:|.|:|::.|||||.:..|..:|:|||.:|.|...|:|.|      |..:     |....
Human   566 EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR------PPGLEYCYNPSHNP 624

  Fly   965 LAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
            ...||.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:
Human   625 EEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-------- 681

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
                       |:...:                                  ||:.:|.
Human   682 -----------HHIDYY----------------------------------KKTTNGR------- 694

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES 1159
             ||::|||||:|...::|.::|:|:||::||||.|||.:||..:...|:.:.:.:|.|.|.|...
Human   695 -LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNC 758

  Fly  1160 RHEFYNLMSRCWHKEPHMRPSFAQ 1183
            .:|.|.:|..|||..|..||:|.|
Human   759 TNELYMMMRDCWHAVPSQRPTFKQ 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	109/338 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	109/334 (33%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	13/78 (17%)
		IG_like	77..151	CDD:214653	13/74 (18%)
		I-set	193..280	CDD:254352	13/88 (15%)
		Ig2_FGFR	196..280	CDD:143265	13/85 (15%)
		IG_like	295..391	CDD:214653	19/102 (19%)
		Ig3_FGFR	303..392	CDD:143175	17/92 (18%)
		PTKc_FGFR1	497..797	CDD:270678	112/354 (32%)
		Pkinase_Tyr	511..787	CDD:285015	110/340 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810