DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Tie1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_035717.2	Gene:	Tie1 / 21846	MGIID:	99906	Length:	1134	Species:	Mus musculus

Alignment Length:	1399	Identity:	297/1399 - (21%)
Similarity:	463/1399 - (33%)	Gaps:	524/1399 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 WLLLLLLVALLLAEAIVAAAAATL------SETQT--------NATNGAIREPPVQLQLQQQQLQ 120
            |...|||..|.||..:.|:...||      ::.|.        .|..|...:||:.|:...:.::
Mouse     4 WGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSDPPLLLEKDDRIVR 68

  Fly   121 -------LQLQLNAT--------------------AGDGESRNSAEIF---SPGDVDVVGDKPTT 155
                   |.|..|.:                    .|...:|.:..::   ||| ..:..||.|
Mouse    69 TFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVLYVHNSPG-AHLFPDKVT- 131

  Fly   156 YRPSGANRPSIAPLNSAQDRERK----------LMNVLAARRTALHRGGFRTRIGTTGRTAISPS 210
               ...|:...|.|::...:|::          ..|.|..:..  ..|.|:.::    :....||
Mouse   132 ---HTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEA--DDGRFQLQL----QNVQPPS 187

  Fly   211 AAVESTSKAPSDP------RSV------------CIRN------------------CTKNFT--- 236
            :.:.|.:...:.|      |.:            |:::                  |...||
Mouse   188 SGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTR 252

  Fly   237 -------RRTTASCMRQCANFT-----RMAMP-----SNGNSSVVLKGSASLKAAAPAGDRDTNE 284
                   .|...||..||....     ...:|     |.|:.   .:||...:|.||
Mouse   253 CEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSG---WRGSQCQEACAP-------- 306

  Fly   285 ILFSDESSHGLF-----VVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYV 344
                     |.|     :..:.|||       ||.....|...||..:.:.
Mouse   307 ---------GHFGADCRLQCQCQNG-------GTCDRFSGCVCPSGWHGVH-------------- 341

  Fly   345 YFGAKLPPIRPGGLTIKAAEGDDDHPRVL----EVSVAQSTTPTITTTST-TPAPVSSTRPTAST 404
                              .|..|..|::|    ||.....|.|.|...:. .|.||   |.:...
Mouse   342 ------------------CEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPV---RGSMKL 385

  Fly   405 RRP--------LTPVERSRSKYKYHMRERGLVPTAAPPPAAPPAPPVSRTRYVGSGRPTAGLSDS 461
            |:|        ...||..|:..::.:                               |:..|.||
Mouse   386 RKPDGTMLLSTKVIVEPDRTTAEFEV-------------------------------PSLTLGDS 419

  Fly   462 -----------IQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSA---------------E 500
                       .||.::.:..|..|.|.....::....|..|:::.|.:               .
Mouse   420 GFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRP 484

  Fly   501 EETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTP--------VPSTSKRTTTNAPLS 557
            :::|:..: |:..|.|   .:.|....||.|..:.....:.|        .||.         |.
Mouse   485 QDSTIAWS-AIVVDPS---ENVTLMNLKPKTGYNVRVQLSRPGEGGEGGWGPSA---------LM 536

  Fly   558 TTNTPTTTTSSTTPSTTTTS------STSTTVIPTTTKANSIIEKDKELIR----ALGPALTREI 612
            ||:.|.........|.....      |.|...:|        :..|..|:|    |.|......|
Mouse   537 TTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSVP--------LSGDGFLLRLWDGARGQERRENI 593

  Fly   613 NIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVL--TSIRSTVHPRPTSTSTTTS 675
            :...|...::       .|:||.|..|      ...::...|:|  .|..:.||..|:.......
Mouse   594 SFPQARTALL-------TGLTPGTHYQ------LDVRLYHCTLLGPASPPAHVHLPPSGPPAPRH 645

  Fly   676 TTTTA------------PPAVTAPSNEVYIGIVESSSSASP--ADI----SSTVIANERDLNMEM 722
            ....|            |.|.:.|.::..:.|..:..|..|  .|:    .:::|.  |.||...
Mouse   646 LHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIV--RGLNAST 708

  Fly   723 RRM--------------NLV---------------------------TLVLVAVGVIP------L 740
            |.:              |.|                           .|||..||.:.      |
Mouse   709 RYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTIL 773

  Fly   741 AAII-LYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQ 804
            ||:: |..:|...:.||...:                      ||....|:.:       :|...
Mouse   774 AALLALVCIRRSCLHRRRTFT----------------------YQSGSGEETI-------LQFSS 809

  Fly   805 NHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVW 869
            ...........|..|:|                        :...|..:|..:.|:||||||||.
Mouse   810 GTLTLTRRPKPQPEPLS------------------------YPVLEWEDITFEDLIGEGNFGQVI 850

  Fly   870 KA--EADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPH 929
            :|  :.|.|..:      .|:|.::..:::...:|   |..::.|||.|.|::.||||| |:..:
Mouse   851 RAMIKKDGLKMN------AAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGAC-ENRGY 908

  Fly   930 MLI-MEYAMRGRLLSLLRAARSATNIL---PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGR 990
            :.| :|||..|.||..||.:|    :|   ||......:.:.||.|.|..||.|.|.||:|::.:
Mouse   909 LYIAIEYAPYGNLLDFLRKSR----VLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEK 969

  Fly   991 RIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYI 1055
            :.:||||||||||:..|...||.|||:|        |.|:.                      |:
Mouse   970 QFIHRDLAARNVLVGENLASKIADFGLS--------RGEEV----------------------YV 1004

  Fly  1056 LQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAF 1120
                                     ||      |:|:   ||:||||.|||.|.::||::|:|:|
Mouse  1005 -------------------------KK------TMGR---LPVRWMAIESLNYSVYTTKSDVWSF 1035

  Fly  1121 GIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSR 1185
            |::||||.:||.|||..:|..|:..::|||.|.:.|:....|.|.||.:||...|:.||.|||..
Mouse  1036 GVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIA 1100

  Fly  1186 LEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            |::.|.|       .|...|:::|.|......|:
Mouse  1101 LQLGRML-------EARKAYVNMSLFENFTYAGI 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	118/337 (35%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	118/335 (35%)
Tie1	NP_035717.2	ig	127..208	CDD:278476	15/90 (17%)
		IG_like	131..210	CDD:214653	14/88 (16%)
		EGF_Lam	225..263	CDD:238012	4/37 (11%)
		EGF_CA	312..343	CDD:238011	8/69 (12%)
		ig	353..439	CDD:278476	20/119 (17%)
		IG	367..441	CDD:214652	16/107 (15%)
		fn3	447..518	CDD:278470	11/74 (15%)
		fn3	546..628	CDD:278470	18/102 (18%)
		FN3	640..732	CDD:238020	15/93 (16%)
		PTKc_Tie1	832..1128	CDD:270671	128/378 (34%)
		TyrKc	835..1103	CDD:197581	121/342 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000