DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Tek

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_038718.2	Gene:	Tek / 21687	MGIID:	98664	Length:	1123	Species:	Mus musculus

Alignment Length:	886	Identity:	197/886 - (22%)
Similarity:	331/886 - (37%)	Gaps:	275/886 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 GRPTAGLSDSIQDLK---QTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPT 513
            |||.  ::..|:||.   :..|....|:.:        :|..|                   |||
Mouse   344 GRPR--MTPQIEDLPDHIEVNSGKFNPICK--------ASGWP-------------------LPT 379

  Fly   514 DESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTT-- 576
            .|..|......|..:|:....|...:..              :.|.|......|.....:..|
Mouse   380 SEEMTLVKPDGTVLQPNDFNYTDRFSVA--------------IFTVNRVLPPDSGVWVCSVNTVA 430

  Fly   577 ------SSTSTTVIPTTTKANSIIEK---------DKELIRALGPALTREINIDDANNLIVFCNN 626
                  .:.|..|:|....|.::|:.         ..|.....||..::::.....|....:...
Mouse   431 GMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVNQAWKYIEV 495

  Fly   627 TSDC----GVTPRTQ-------TQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTS----TTTST 676
            |::.    .:.|||.       .:|....:..|..:|.....||..   |.|...|    :.|:.
Mouse   496 TNEIFTLNYLEPRTDYELCVQLARPGEGGEGHPGPVRRFTTASIGL---PPPRGLSLLPKSQTAL 557

  Fly   677 TTTAPPAVTAPSNEVYIGIVESSSSAS--------PADISSTVIAN-----------------ER 716
            ..|..|..|...:|.|:.:...|...:        |.:::|.:::|                 :.
Mouse   558 NLTWQPIFTNSEDEFYVEVERRSLQTTSDQQNIKVPGNLTSVLLSNLVPREQYTVRARVNTKAQG 622

  Fly   717 DLNMEMRRMNL------------VTLVLVAVGVIPLAAIILYLVRNFVIRRRAK---QSEVFDVC 766
            :.:.|:|...|            ::.:..:..::....:..|.:.:.:||.:.:   :.:..||.
Mouse   623 EWSEELRAWTLSDILPPQPENIKISNITDSTAMVSWTIVDGYSISSIIIRYKVQGKNEDQHIDVK 687

  Fly   767 ITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQAS------- 824
            |.:        ...::||:...|.|..:......:::....|.......:.:|.|.||
Mouse   688 IKN--------ATVTQYQLKGLEPETTYHVDIFAENNIGSSNPAFSHELRTLPHSPASADLGGGK 744

  Fly   825 --------------------------------QRD---------------------ANHNRYGNN 836
                                            ||.                     |.:.:..||
Mouse   745 MLLIAILGSAGMTCITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFNSGTLALNRKAKNN 809

  Fly   837 DDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQVS 899
            .|.|.    :...:.::|:.:.::||||||||.||  :.|      |.....|:|.::..:::..
Mouse   810 PDPTI----YPVLDWNDIKFQDVIGEGNFGQVLKARIKKD------GLRMDAAIKRMKEYASKDD 864

  Fly   900 LKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNIL---PAS 958
            .:|   |..::.|||.|.|::.|||||.......|.:|||..|.||..||.:|    :|   ||.
Mouse   865 HRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR----VLETDPAF 925

  Fly   959 VPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDA 1023
            .....:.:.||.:.|..||.|:|.||:|::.::.:||||||||:|:..|.:.||.|||:|
Mouse   926 AIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLS----- 985

  Fly  1024 ERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHD 1088
                :.||.                     |:                         ||
Mouse   986 ----RGQEV---------------------YV-------------------------KK------ 994

  Fly  1089 TIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRP 1153
            |:|:   ||:||||.|||.|.::||.:|:|::|::||||.:||.|||..:|..|:..::|||.|.
Mouse   995 TMGR---LPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 1056

  Fly  1154 DLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHK 1194
            :.|.....|.|:||.:||.::|:.||||||..:.:.|.|.:
Mouse  1057 EKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEE 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/336 (34%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	116/334 (35%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:287411
		EGF_Lam	230..275	CDD:238012
		EGF_2	311..340	CDD:285248
		fn3	445..516	CDD:278470	11/70 (16%)
		fn3	542..625	CDD:278470	13/82 (16%)
		FN3	638..730	CDD:238020	11/99 (11%)
		PTKc_Tie2	815..1117	CDD:133219	119/357 (33%)
		STYKc	823..1091	CDD:214568	117/341 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000