DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Srms

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_035611.3	Gene:	Srms / 20811	MGIID:	101865	Length:	507	Species:	Mus musculus

Alignment Length:	348	Identity:	103/348 - (29%)
Similarity:	154/348 - (44%)	Gaps:	91/348 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGS--H 913
            ||...|:..||||.||:||:       |.:..:..||||.|:  ||.:.|.|....:..|.|  |
Mouse   242 RSEFVLRRKLGEGFFGEVWE-------GLWLGSIPVAVKVIK--SADMKLADLTKEIEALKSLRH 297

  Fly   914 QNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFAL 978
            :.::.|...|...||..::.|...:|.|...|.::......||               .|.|||.
Mouse   298 ERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLP---------------HLLGFAC 347

  Fly   979 DIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNA 1043
            .:|.||.|:..||:|||||||||||:..:..||:.|||::      |:.|:...:.::
Mouse   348 QVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLA------RLLKDDVYSPSS------- 399

  Fly  1044 HKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQY 1108
                   ||:                                          :|::|.|||:..|
Mouse   400 -------GSK------------------------------------------IPVKWTAPEAANY 415

  Fly  1109 HMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHK 1173
            .:|:.::|:|:|||:|:|:.|.|..||..:|..|.::::.:|.|...|.....|.|.||..||..
Mouse   416 RVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKG 480

  Fly  1174 EPHMRPSFAQSRLE---ITRSLH 1193
            .|..||:||..|.:   |.|.||
Mouse   481 SPEERPTFAILREKLNAINRRLH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	95/330 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	96/328 (29%)
Srms	NP_035611.3	SH3	70..124	CDD:302595
		SH2_Srm	134..212	CDD:198223
		PTKc_Srm_Brk	238..498	CDD:133248	99/341 (29%)
		STYKc	246..495	CDD:214568	97/334 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010