DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Ret

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_033076.2	Gene:	Ret / 19713	MGIID:	97902	Length:	1115	Species:	Mus musculus

Alignment Length:	790	Identity:	195/790 - (24%)
Similarity:	293/790 - (37%)	Gaps:	253/790 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 KVSPSSSTPLIITVLSAEEETT----VGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPV 543
            |:.|||.....:.|:::.|:|:    |..||||...|.|....|...|:: .|...|..:....|
Mouse   443 KLQPSSINCTALGVVTSPEDTSGTLFVNDTEALRRPECTKLQYTVVATDR-QTRRQTQASLVVTV 506

  Fly   544 PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPAL 608
            ..||.......|.|      ...:...|.........:   ||..         .|..:..|..:
Mouse   507 EGTSITEEVGCPKS------CAVNKRRPECEECGGLGS---PTGR---------CEWRQGDGKGI 553

  Fly   609 TREINIDDANNLIVFCNNTSDCGVTPRTQTQP--------SHTTDSSPK-ILRTTVLTSIRSTVH 664
            ||               |.|.|  :|.|:|.|        |...:..|: .||..::..     |
Mouse   554 TR---------------NFSTC--SPSTRTCPDGHCDAVESRDANICPQDCLRADIVGG-----H 596

  Fly   665 PRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIV-----ESSSSASPADISSTVIANERDLNMEMRR 724
            .|.........                 .||.     |......|.|....:        .:...
Mouse   597 ERGERQGIKAG-----------------YGICNCFPDEKKCFCEPEDSQGPL--------CDALC 636

  Fly   725 MNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDE 789
            ..::|..|.::    :.:|:|               .:|.||
Mouse   637 RTIITAALFSL----IISILL---------------SIFCVC----------------------- 659

  Fly   790 DEVDHQHHQHMQHHQNHQNHQNH---------QHHQAMPMSQAS------QRDANHNRYGNNDDK 839
                 .||:|        .|:..         :..|..|:|.:|      ..|:..|:...:..|
Mouse   660 -----HHHKH--------GHKPPIASAEMTFCRPAQGFPISYSSSGTRRPSLDSTENQVPVDSFK 711

  Fly   840 TSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD-- 902
            .....:: :|.|.|:.|...||||.||:|.||.|..|.|..|.| .||||.::..::|..|:|
Mouse   712 IPEDPKW-EFPRKNLVLGKTLGEGEFGKVVKATAFRLKGRAGYT-TVAVKMLKENASQSELRDLL 774

  Fly   903 -EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSL- 965
             |.|::::: :|.:|:.|.|||.:..|.:||:|||..|.|...||.:|   .|.||.|.||.|.
Mouse   775 SEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSR---KIGPAYVSGGGSRN 835

  Fly   966 ---------APLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL 1021
                     ..|:...|..||..|:.||:|:|..::|||||||||:|:......||.|||:|.|:
Mouse   836 SSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDV 900

  Fly  1022 DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHG 1086
            ..|                           ..|:                         |||
Mouse   901 YEE---------------------------DSYV-------------------------KKS--- 910

  Fly  1087 HDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGL 1151
                  :..:|::|||.|||..|::||::|:|:||::||||.|||..||..:....:...:..|.
Mouse   911 ------KGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGH 969

  Fly  1152 RPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS------- 1209
            |.:.|.....|.|.||.:||.:||..||.||    :|::.|.|.:   ..:.||:|::
Mouse   970 RMERPDNCSEEMYRLMLQCWKQEPDKRPVFA----DISKDLEKMM---VKSRDYLDLAASTPSDS 1027

  Fly  1210 -----GFSED 1214
                 |.||:
Mouse  1028 LLYDDGLSEE 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	116/341 (34%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	116/339 (34%)
Ret	NP_033076.2	Cadherin	173..262	CDD:278457
		PTKc_RET	724..1013	CDD:173631	121/361 (34%)
		Pkinase_Tyr	725..1006	CDD:285015	118/350 (34%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900