Protein Alignment Tie and T25B9.4

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_501994.1
• Gene: T25B9.4 / 188882
• WormBaseID: WBGene00012010
• Length: 546
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 100/471 - (21%)
• Similarity: 178/471 - (37%)
• Gaps: 137/471 - (29%)

  Fly   750 NFVIR---RRAKQSEVFDVCITDQQPISPVKKVDSK----YQVDDDEDEV--DHQHHQHMQHHQN 805
            :|:.|   |...:.:..|:.::...|...|..:|:|    |.::...:.|  |.:...|
 Worm    35 DFIFRVTERTVGKEQKKDIVLSIAWPTESVAMIDTKDIKNYLIERSANSVWLDLKISFH------ 93

  Fly   806 HQNHQNHQHHQAMPMSQASQRDANHNRYGNND-----DKTSLASE----FHDFERSNIRLKSLLG 861
                               ..||.:|.|..|:     .:..|...    |.:|:.|.|.|...:|
 Worm    94 -------------------SIDALYNHYRKNELVHPNLRIKLGRPICLFFWEFKHSQINLIKKVG 139

  Fly   862 EGNFGQVWKAEADDLSGHFGATRIVAVKTIR--ACSAQVSLKD---EANIMRKLGSHQNVVTLLG 921
            :|.:|:|:|......:..|..    |:|.:|  ..:....:|:   ||.:||.| :|.|:|...|
 Worm   140 KGAYGEVFKGTVTRGNKTFNG----AIKAMRKDLDAGNEKMKEVMAEARLMRSL-NHPNIVRCRG 199

  Fly   922 ACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEY 986
            ..|..:|..:::|:...|.|.|.|:                ::...|:.......|:..|.|:|:
 Worm   200 IAVLEQPVYIVIEFINGGGLDSYLK----------------KNSQTLTMDQKNRMAISAAWGIEF 248

  Fly   987 IAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFG 1051
            :....|:|||:||||.|.|:..:.|:.|||:|......||:|..:
 Worm   249 MHSHDIIHRDIAARNCLYDNKNLVKLSDFGLSRKGSVYRMKKAMK-------------------- 293

  Fly  1052 SRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETD 1116
                                                        :|.:|:|||||....|:..:|
 Worm   294 --------------------------------------------MPTKWLAPESLTTFTFSGASD 314

  Fly  1117 IWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSF 1181
            ::.||::|:||.|. ..||..:...|..|.:..|..|:..|::..|...::.:..::   :.|:.
 Worm   315 VYTFGVLLYEIYTC-QEPYLAVKAGEAKRYILSGAFPNFTKQAPPELNEIVKKSIYQ---LDPAK 375

  Fly  1182 AQSRLEITRSLHKWVD 1197
            ..:...|.:.|..|:|
 Worm   376 RDTMKVIVKKLETWLD 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	75/333 (23%)
		PTKc	860..1187	CDD:270623	73/331 (22%)
T25B9.4	NP_501994.1	SH2_Fps_family	9..109	CDD:198224	17/98 (17%)
		TyrKc	132..386	CDD:197581	76/342 (22%)
		PTKc	136..387	CDD:270623	74/339 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950