Protein Alignment Tie and T06C10.3

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_501307.1
• Gene: T06C10.3 / 188160
• WormBaseID: WBGene00020289
• Length: 557
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 119/596 - (19%)
• Similarity: 206/596 - (34%)
• Gaps: 185/596 - (31%)

  Fly   572 STTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRT 636
            |.::|||:|:..|||.:                .||:                |..|.....|..
 Worm    22 SKSSTSSSSSNSIPTQS----------------APAM----------------NAASSPSKEPAK 54

  Fly   637 QTQPSHTTD-SSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSS 700
            |.:.....: ...|.:..:|...:...|..:..||..|.::     ..:.||..:......:.|:
 Worm    55 QEKEDDKKEVEEKKEIEKSVEAKVEGKVKAKVESTQNTDNS-----QELKAPEEKPKKKKKKKSN 114

  Fly   701 SASPADISSTVIANERD----LNMEMRRMNLVTLVLVAVGVIPLAAI--ILYLVRNFVIRRRAKQ 759
            ....|.:....|..|::    |..::|..|...      |.:|...:  .|:...:|::|    .
 Worm   115 LIVSASVEKLSIVPEKEDFSILEKKLREFNFYH------GFLPREDLHTTLHNPGDFLLR----V 169

  Fly   760 SEVFD-------VCITDQQPISPVKKVDSKYQVDDDED-----EVDHQHHQHMQHHQNHQNHQNH 812
            |||.:       ..|....|:|.|.|        |:||     .|..:...::...:..:..::.
 Worm   170 SEVVEGEHKVNREVILSLIPVSTVSK--------DEEDRKKVRNVVIKRVTNLFFCEITRTFESI 226

  Fly   813 Q----HHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEA 873
            .    ::...|...||         |....|..:..:..:|..|::.:..:||||.||:|
 Worm   227 SDLVTYYTKNPGGCAS---------GTFQLKHPILQQSWEFMHSDVTVGKVLGEGAFGKV----- 277

  Fly   874 DDLSGHF----GATRIVAVK--TIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPH 929
              .||..    |....||:|  .:.|..:::.:|:   ||..:|.. :|:|||.|.|.....:|.
 Worm   278 --CSGTLKLKDGTNVDVAIKMTKVSAFLSKMKIKEMMNEARFIRNF-NHKNVVRLYGVAHHEQPL 339

  Fly   930 MLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVH 994
            .:::|....|.|...::..:.|.:|:..                ..|......|:||:.....:|
 Worm   340 YILLELVKGGSLQDHMKKEKGAVSIVEK----------------IKFCSGAGRGIEYLHQNNCIH 388

  Fly   995 RDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHW 1059
            ||:||||.|| |....||.|||:|......:|:..
 Worm   389 RDIAARNCLL-HEKEVKITDFGLSRTGPVYKMKTA------------------------------ 422

  Fly  1060 QHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVL 1124
                        |.                      ||::|:|||:|....|:..||.:::|:..
 Worm   423 ------------CK----------------------LPVKWLAPETLSTLSFSFATDTYSWGVTC 453

  Fly  1125 WEIATLGSTPY 1135
            :|:...|..|:
 Worm   454 YEVFADGVEPF 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	66/291 (23%)
		PTKc	860..1187	CDD:270623	66/285 (23%)
T06C10.3	NP_501307.1	SH2_Fps_family	138..236	CDD:198224	19/115 (17%)
		TyrKc	263..517	CDD:197581	66/291 (23%)
		PTKc	267..518	CDD:270623	66/287 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010