DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and R151.1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001299880.1	Gene:	R151.1 / 187907	WormBaseID:	WBGene00020106	Length:	696	Species:	Caenorhabditis elegans

Alignment Length:	1014	Identity:	210/1014 - (20%)
Similarity:	340/1014 - (33%)	Gaps:	378/1014 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 DPRSVCIRNCTKNFTRRTTASCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEIL 286
            :.||.|:.:|:...|.:....|:.:|:.     .|...|     .|.:.|.|..|.......::
Worm    24 EQRSDCVESCSHLDTSQEFGDCLAKCSK-----RPRKDN-----LGDSHLFAMPPTNVEIETKV- 77

  Fly   287 FSDESSHGLFVVAKEQNGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLP 351
                                  |.||      ||.:.:..|...|:.:...:..  |:.:.|
Worm    78 ----------------------IMDG------GKILETTINWKADEKDTRREGF--YIRYTA--- 109

  Fly   352 PIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRS 416
                                  ..|..|...|...|:|..|...|.|.|:|.....|. ::.|.|
Worm   110 ----------------------VNSTCQKHFPGYFTSSILPDERSLTIPSAFNGHALV-IDHSCS 151

  Fly   417 KYKYHMRERGLVPTAAPPPAAPPAPP------VSRTRYVG-------SGRP--TAGLSD------ 460
               ||::.|           |.|.||      :.|...|.       |.||  .|.:.|
Worm   152 ---YHLQIR-----------AKPYPPGDDKYIIERRHTVPDCIDKYCSCRPGDVAAIRDVSVDAE 202

  Fly   461 -----SIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTT 520
                 ...::|..|.:....|..|:        :.|||....|..|           ::|.|...
Worm   203 YRLNWKFDEMKGREYQFYVDVYERI--------AMPLIKKKGSEPE-----------SEEYTFRI 248

  Fly   521 STTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIP 585
            :...:.|..:.:..||.            .|....|....||
Worm   249 ANADSYEISAKSAETSA------------HTYQYQLPFQFTP----------------------- 278

  Fly   586 TTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKI 650
                    .::.|..|.|          :||:     ||:|.....:...|     :.|.||.:|
Worm   279 --------FQQYKISIFA----------VDDS-----FCHNQDVFHIFNTT-----NATFSSSEI 315

  Fly   651 LRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANE 715
            .:||.:..|         |.|..|.||.                ::|||.
Worm   316 PKTTPIPEI---------SGSAITKTTM----------------LMESSI--------------- 340

  Fly   716 RDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVD 780
                       ||..::|...:.|:..:|:.|    .:|||.|:                :||
Worm   341 -----------LVIFLIVVACMSPICTMIVLL----CLRRRKKE----------------IKK-- 372

  Fly   781 SKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASE 845
                                :||..|:...:...|..:. :....|..|....|...:..
Worm   373 --------------------RHHFLHRRSLSCSRHSIIE-TNILYRPPNEVNGGTTGEWL----- 411

  Fly   846 FHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIM 907
               ....:|.:.:::|||.||||:|.   .|.|..|....||||.::|.:.....::   |..:|
Worm   412 ---IRGQDIVVGAVIGEGAFGQVFKG---ILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMM 470

  Fly   908 RKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRT 972
            :.:|.|.|:||:.|.|::.:...:||||...|.|...|:..|...:          |.:.:..:.
Worm   471 QTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKD----------SDSAIDSKE 525

  Fly   973 LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAAND 1037
            ...|...|||||.::....|:||||||||:|:....:.||.|||||
Worm   526 FLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMS------------------- 571

  Fly  1038 LMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMA 1102
                                                  :|....|...|        .:|:||::
Worm   572 --------------------------------------RPGVYIKMSKG--------VIPLRWLS 590

  Fly  1103 PESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLM 1167
            ||:::.:.::.::|:||||::||||||||..||:.:..::::.::.:|:|.:.|.:...:.|.||
Worm   591 PEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILM 655

  Fly  1168 SRCWHKEPHMRPSFAQ--SRLEITRSLHKWVDDDSAASD 1204
            ..||:.:...||||..  |::|...:    ||.|:..||
Worm   656 KSCWNLKAEDRPSFLAILSKIEQIAN----VDADAPPSD 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	93/331 (28%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	93/331 (28%)
R151.1	NP_001299880.1	PTKc	422..677	CDD:270623	93/332 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900