Protein Alignment Tie and F59F5.3

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_509765.2
• Gene: F59F5.3 / 186634
• WormBaseID: WBGene00010342
• Length: 681
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 141/732 - (19%)
• Similarity: 239/732 - (32%)
• Gaps: 236/732 - (32%)

  Fly   521 STTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNA--------------PLSTTNTPTTTTSSTTP 571
            |:..|||...|.||...|      .:..|.|.|:              .:...||..:..:.|..
 Worm    99 SSRLTTESDDTHTSVDLT------HSKIRCTRNSIEIMKFHMFVGRDDNMFFKNTIVSKLNGTGV 157

  Fly   572 STTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCG----- 631
            ....:.|..|..:       .::|..|.|.....|  .:...||.:.|.|   |....|.
 Worm   158 YLQCSGSYHTENV-------KLLENQKSLDIPYNP--FKGFYIDISRNPI---NRFYQCEHNDEL 210

  Fly   632 VTPRTQTQPSHTTDSSPKILRTT-VLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAP-------- 687
            ::.:.|...::..::..|:|..: ...|....|.......:|..|.....|.....|
 Worm   211 ISFKLQNMANNGYENKFKMLMNSYTFQSEIQCVFDDQAIKNTHVSVILACPSKSKCPELTNRANR 275

  Fly   688 -SNEVYIGIVESSSSASPADISSTVIANER---DLNMEMRRMNLVTLVLVAVGVIPLAAIILYLV 748
             |:::|...|..||:..|......:|.|..   :..:|....:.....|:.:|    |.:||.:
 Worm   276 RSHKIYTAFVPKSSNIDPKSYHCVLIINGNTVAEAFLEEADFSTTYYALLIIG----AGLILTI- 335

  Fly   749 RNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQ 813
              |||..:
 Worm   336 --FVILTK--------------------------------------------------------- 341

  Fly   814 HHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSG 878
                      |.|..|:|:....|.:.:...|.::        ||.||.||...::.||
 Worm   342 ----------SLRQNNYNKVSTTDVRETRIEELNN--------KSKLGVGNSSTIYTAE------ 382

  Fly   879 HFGATR--IVAVKTIRACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESE----------PHML 931
             ...|:  ||..:::|.......||    :::.| .|.|::|.||..|:.|          .|:|
 Worm   383 -ICKTKKCIVIKESVRKSHCTKELK----LLKSL-KHPNIITPLGVIVQPEQKTCFNVQIRQHLL 441

  Fly   932 IMEY---AMRGRLLSLLRAARSATNIL---PASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGR 990
            :..|   .:...:.......|...||.   .|:||.    ..::...|...|..:|..:||:.|.
 Worm   442 LPYYQKTCLETYIHKFYPPKRGGNNIFHTNEATVPE----EEITMFDLVSIAWQVASALEYLKGM 502

  Fly   991 RIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYI 1055
            .|.|||:|.||||:.:|.:|||.||        ||.:|.:           ...|...:...:.|
 Worm   503 EITHRDVAMRNVLISNNKVCKITDF--------ERAKKGE-----------TTRKISIEKKIKEI 548

  Fly  1056 LQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQ--YHMFTTETDIW 1118
            |            :.|.|||.|    |.:..                 |.|:  |:.:::|  ::
 Worm   549 L------------KAHMSKDIP----KEYPN-----------------ECLKGVYYYYSSE--VY 578

  Fly  1119 AFG-IVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFA 1182
            .|| ::|...:.:....|.::            ..|..|:......|:|:..|.::....|||.:
 Worm   579 CFGRLMLCLFSFMKPCDYGRI------------YPPIQPENCPKAIYDLIVDCINENRKSRPSIS 631

  Fly  1183 QSRLEITRSLHKWVDDD 1199
            ..: ::..::.|.:|.|
 Worm   632 SCK-DVLSTVLKHMDHD 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	80/349 (23%)
F59F5.3	NP_509765.2	PK_Tyr_Ser-Thr	<413..637	CDD:462242	65/294 (22%)