DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Pdgfra

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001076785.1	Gene:	Pdgfra / 18595	MGIID:	97530	Length:	1089	Species:	Mus musculus

Alignment Length:	1178	Identity:	262/1178 - (22%)
Similarity:	402/1178 - (34%)	Gaps:	396/1178 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 RMAMPS---NGNSSVV-LKGSASLKAAA--------PAGDR-DTNEILFSDESSHGLFVVAKE-Q 302
            ::.:||   |.|..:| |..|.||:...        |..:. |.|..:.|:|::.||||...| .
Mouse    24 QLLLPSILPNENEKIVQLNSSFSLRCVGESEVSWQHPMSEEDDPNVEIRSEENNSGLFVTVLEVV 88

  Fly   303 NGTLNHIADGTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFGAKLPPIR--PGGLT--IKAA 363
            |.:..|....|          ...|..:.|..|.|..   ::|.....|.:.  |.|:|  :...
Mouse    89 NASAAHTGWYT----------CYYNHTQTDESEIEGR---HIYIYVPDPDMAFVPLGMTDSLVIV 140

  Fly   364 EGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRERGLV 428
            |.||              :..|...:|.|    .|:.|......|.|.       .|..|: |..
Mouse   141 EEDD--------------SAIIPCRTTDP----ETQVTLHNNGRLVPA-------SYDSRQ-GFN 179

  Fly   429 PTAAPPPAAPPAPPVSRT-----RYVGSGRPTAGLSDSIQDLKQTESEVAKPVV-------RRVV 481
            .|.:..|....|....||     ..|.:.:.|:.|:..: |.:||..:..:.:|       ..||
Mouse   180 GTFSVGPYICEATVKGRTFKTSEFNVYALKATSELNLEM-DARQTVYKAGETIVVTCAVFNNEVV 243

  Fly   482 --QKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVP 544
              |...|.......||:|   ||.      .||:.:...|.:....|.|.|.....:....|...
Mouse   244 DLQWTYPGEVRNKGITML---EEI------KLPSIKLVYTLTVPKATVKDSGEYECAARQATKEV 299

  Fly   545 STSKRTT-------------TNAPLSTTNT------PTTTTSSTTPSTTTTSSTSTTVIPTTTKA 590
            ...||.|             |...|...|.      .....:..||..:.... :.|:|...|:.
Mouse   300 KEMKRVTISVHEKGFVEIEPTFGQLEAVNLHEVREFVVEVQAYPTPRISWLKD-NLTLIENLTEI 363

  Fly   591 NSIIEKDKE--------LIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSS 647
            .:.::|.:|        ||||      :|   :|:.:..:...|..|.         .|:|.:
Mouse   364 TTDVQKSQETRYQSKLKLIRA------KE---EDSGHYTIIVQNEDDV---------KSYTFE-- 408

  Fly   648 PKILRTTVLTSIRSTVHPRPTS----TSTTTSTTTTAPPA-------VTAPSNEVYIGIVESSSS 701
               |.|.|..||...|.....|    |...|:..|..|..       :...:|:....::.|:.|
Mouse   409 ---LSTLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHIKKCNNDTSWTVLASNVS 470

  Fly   702 -----------------ASPADISSTVIAN---ERDLNMEMRRMNLVT------LVLVAVGVIPL 740
                             .|.|.:..|:...   :.:|::..|.:.||.      |.:.|..::.|
Mouse   471 NIITELPRRGRSTVEGRVSFAKVEETIAVRCLAKNNLSVVARELKLVAPTLRSELTVAAAVLVLL 535

  Fly   741 AAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQN 805
            ..:|:.|:...||   .||...:::.....:.|||
Mouse   536 VIVIVSLIVLVVI---WKQKPRYEIRWRVIESISP------------------------------ 567

  Fly   806 HQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWK 870
                ..|::....||.....     :|:              :|.|..:.|..:||.|.||:|.:
Mouse   568 ----DGHEYIYVDPMQLPYD-----SRW--------------EFPRDGLVLGRILGSGAFGKVVE 609

  Fly   871 AEADDLSGHFGATRI-----VAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESE 927
            ..|      :|.:|.     ||||.::   ..|.:.:|..|..||..||.|.|:|.|||||.:|.
Mouse   610 GTA------YGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSG 668

  Fly   928 PHMLIMEYAMRGRLLSLLRAARSA---------------TNILPAS------------------- 958
            |..:|.||...|.|::.|...|.:               ..:.||.
Mouse   669 PIYIITEYCFYGDLVNYLHKNRDSFMSQHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYMD 733

  Fly   959 ---------VPG------------GRSL--APLSPR------------------------TLAGF 976
                     ||.            .|||  .|.|.:                        .|..|
Mouse   734 MKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDDSEGLTLLDLLSF 798

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRH 1041
            ...:|.|||::|.:..||||||||||||....:.||||||:                 |.|:|..
Mouse   799 TYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGL-----------------ARDIMHD 846

  Fly  1042 NAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESL 1106
            :.:..|   ||.:                                         ||::||||||:
Mouse   847 SNYVSK---GSTF-----------------------------------------LPVKWMAPESI 867

  Fly  1107 QYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRC 1170
            ..:::||.:|:|::||:||||.:||.||| ..:.......::..|.|...|..:..|.|.:|.:|
Mouse   868 FDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQC 932

  Fly  1171 WHKEPHMRPSFAQSRLEITRSL--------HKWVDDDSAASDYMDVSGFSEDLEH---GVVYFNH 1224
            |:.||..||||.... ||..:|        ::.:..|...||:..|:....|.::   ||.|.|.
Mouse   933 WNSEPEKRPSFYHLS-EIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNE 996

  Fly  1225 --RISEFE 1230
              ::.::|
Mouse   997 EDKLKDWE 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	115/418 (28%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	114/416 (27%)
Pdgfra	NP_001076785.1	Ig_3	28..100	CDD:372822	22/81 (27%)
		Ig_PDGFR-alphabeta	228..311	CDD:143269	20/91 (22%)
		Ig4_PDGFR	313..413	CDD:143267	22/123 (18%)
		Ig_TrkABC_d4	416..497	CDD:143173	13/80 (16%)
		PTKc_PDGFR_alpha	555..956	CDD:173653	127/521 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1089
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000