DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and abl-1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_509778.2	Gene:	abl-1 / 181261	WormBaseID:	WBGene00000018	Length:	1224	Species:	Caenorhabditis elegans

Alignment Length:	701	Identity:	157/701 - (22%)
Similarity:	258/701 - (36%)	Gaps:	199/701 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 STSKRTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALT 609
            ||.|....| .|.|...|.......:|.:..:|..:                 :|:.|:..| |.
Worm     6 STGKEINDN-ELFTCEDPVFDQPVASPKSEISSKLA-----------------EEIERSKSP-LI 51

  Fly   610 REINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTT 674
            .|::....:::.:| ..|.|....|.:.:.....:.|...::..:.:.|: :.||    ..:|.:
Worm    52 LEVSPRTPDSVQMF-RPTFDTFRPPNSDSSTFRGSQSREDLVACSSMNSV-NNVH----DMNTVS 110

  Fly   675 STTTTAPPAVTAPSNEVYIGIVESSSSASPAD-------------ISSTVIANERDLNMEMRRMN 726
            |:::::.|...|..:  :.|:.|...|....|             ..:.:.:..::.....||:.
Worm   111 SSSSSSAPLFVALYD--FHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDASNQRRLG 173

  Fly   727 LVTLVLVAVGVIPLAAIILY-------------------------LVRNFVIRRRAKQSEVFDVC 766
                   .:|.:|...|..|                         :..:|::|........:.:.
Worm   174 -------EIGWVPSNFIAPYNSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTIS 231

  Fly   767 ITDQQPISPVKKVDSKYQVDDDE-----DEVDHQHHQHMQHHQNHQNHQNHQHHQ----AMPMSQ 822
            :.....:     ...:..||:.|     .||..:....:.||        |..|.    .:.|..
Worm   232 VRHDGRV-----FHYRINVDNTEKMFITQEVKFRTLGELVHH--------HSVHADGLICLLMYP 283

  Fly   823 ASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQV----WKAEADDLSGHFGAT 883
            ||::|.....:..:.:    |.:..:.:||.|.:.:.||.|.:|.|    ||..  |.:
Worm   284 ASKKDKGRGLFSLSPN----APDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRH--DCT------ 336

  Fly   884 RIVAVKTIRACSAQV-SLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRA 947
              :|||.::..:..: ....||.||:.| .|:|:|.|||.|....|..:|.|:...|.||..||
Worm   337 --IAVKALKEDAMPLHEFLAEAAIMKDL-HHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLR- 397

  Fly   948 ARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKI 1012
             |:..::||             |..|...|..||.||.|:..|..:||||||||.|:..:.:.||
Worm   398 -RTDKSLLP-------------PIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEHNIVKI 448

  Fly  1013 CDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQP 1077
            .|||::      |..||....|      |...||
Worm   449 ADFGLA------RFMKEDTYTA------HAGAKF------------------------------- 470

  Fly  1078 HGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGRE 1142
                               ||:|.|||.|.::.|::::|:||||::||||||.|..||..:....
Worm   471 -------------------PIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVELSN 516

  Fly  1143 VIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLH 1193
            |...:..|.|.|.|:......|.||.:||:..|..||.|        |.:|
Worm   517 VYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRF--------RDIH 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	101/333 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	100/331 (30%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	10/74 (14%)
		SH2_ABL	190..283	CDD:198189	12/105 (11%)
		PTKc_Abl	304..566	CDD:270645	105/352 (30%)
		Pkinase_Tyr	311..562	CDD:285015	103/345 (30%)
		FABD	1091..1224	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920