Protein Alignment Tie and kin-9

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001257058.1
• Gene: kin-9 / 181098
• WormBaseID: WBGene00002195
• Length: 585
• Species: Caenorhabditis elegans
• Alignment Length: 760
• Identity: 164/760 - (21%)
• Similarity: 268/760 - (35%)
• Gaps: 247/760 - (32%)

  Fly   487 SSSTPLIITVLSAEEETTVGQTEALPT---DESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSK 548
            :||..|:.|:             |.||   |:|....|...:.:       .||.|.:|.|||..
 Worm    10 ASSAALVSTL-------------AFPTPAVDDSHEDWSAYKSRK-------YSTWTPSPQPSTMN 54

  Fly   549 RTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREIN 613
            ..|.....:..|.......:.:||......|.|.:   :.:|.:.::...:.|..:.|.:|.
 Worm    55 AGTQTDFRTARNENDNQNHNLSPSDIRYLETITNL---SQQALNNVKSTIDTINEVEPPITS--- 113

  Fly   614 IDDANNLIVFCNNTSDCGVTPRTQ------TQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTST 672
                               .||:|      .||......:.:......|.......||.......
 Worm   114 -------------------PPRSQYQAPWNNQPYQQGSWASQYAPYPTLPPEHLVFHPHKPPHHQ 159

  Fly   673 TTSTTTTAPPAVTAPSN--------EVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVT 729
            ..|.....||....|.:        :.|.|..:.||...                        |.
 Worm   160 DDSLEKNPPPPPHKPRHLPTTPLYYDPYYGGDKHSSEGG------------------------VN 200

  Fly   730 LVLVAVGV-IPLAAII--LYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDE 791
            .|.:.:|: |||..|.  |.|...|..|:|.:|::       :|.|:...||      |:|.|.:
 Worm   201 AVALGLGIGIPLGIIAFGLALFIFFWCRKRRRQNK-------NQFPLPFPKK------VNDYETQ 252

  Fly   792 VDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHD---FERSN 853
            :|                                               |.|...||   .:|:|
 Worm   253 LD-----------------------------------------------SPAYSIHDPWLLDRNN 270

  Fly   854 IRL--KSLLGEGNFGQVWKAEADDLSGHFGATRI-------------VAVKTIRACSAQVSLKD- 902
            :.:  ...||.|.|..|:|.:   ::|....::|             ||||.:.:.:...:..|
 Worm   271 LEINYSKKLGSGAFCNVFKGK---INGEAPVSQIHPGQRTQLLRDCPVAVKMLPSFADDAARSDF 332

  Fly   903 --EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSL 965
              |.|.|:.|..|.::|::||...:.:...|::|:...|.||.::|..|......|...|.|
 Worm   333 MQEINFMKSLAYHPHLVSMLGFVADRKSPYLLVEFCEHGDLLHMIRNRRQEIINGPTENPDG--- 394

  Fly   966 APLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQ 1030
              |..:.|..|:..|:.|:||:.....:|||:||||||:|....|||.|||:.
 Worm   395 --LKIKDLLMFSWQISNGLEYLNNIGCIHRDIAARNVLVDSANTCKIGDFGLC------------ 445

  Fly  1031 EKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHA 1095
               ...|.:.:.|.      |.|
 Worm   446 ---RLTDSLLYTAR------GGR------------------------------------------ 459

  Fly  1096 LPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESR 1160
            ||::|||||||..:.::.::|:|::|::|||:.:||..||.::...|:::....|.|...|:...
 Worm   460 LPLKWMAPESLATYEYSYKSDVWSYGVLLWELFSLGEVPYGEVQTTELLQTHRSGKRLLKPEWCP 524

  Fly  1161 HEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDY 1205
            .|.|::|..||.:.|..||:|.|:...:.:.|      ::|..:|
 Worm   525 EEIYDVMRLCWQELPDDRPAFQQTCAVLAQML------ENATENY 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	90/346 (26%)
		PTKc	860..1187	CDD:270623	91/342 (27%)
kin-9	NP_001257058.1	SKG6	194..230	CDD:370068	13/59 (22%)
		PTKc	277..557	CDD:270623	92/356 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010