Protein Alignment Tie and F09G2.1

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_001343836.1
• Gene: F09G2.1 / 179108
• WormBaseID: WBGene00017310
• Length: 994
• Species: Caenorhabditis elegans
• Alignment Length: 738
• Identity: 163/738 - (22%)
• Similarity: 270/738 - (36%)
• Gaps: 232/738 - (31%)

  Fly   517 TTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTSSTTPSTTT------ 575
            |.....|.||.:|:||.   |:|:||.|:.......:..::.....|..||....|...
 Worm   270 TLDVCATPTTAEPTTTV---TSTSTPKPTLDPEYLNDWQITYLFAITNRTSQEQFSRLVKYISDP 331

  Fly   576 --TSSTSTTVIPTTTKANS----IIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCG--- 631
              ..|....:|....:.||    |.:.|:     :.|.| ::::.|:.  ||...|.|...|
 Worm   332 LEDCSGKAMIIRFLARNNSNSGWISDVDQ-----VAPYL-QQLSYDEV--LIASDNRTLLPGNDN 388

  Fly   632 -----VTPRTQTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPP-------AV 684
                 |.....|.|.:..|.:..:.:..:||...|.|.        .....||..|       ::
 Worm   389 VTFDLVWEAVSTSPCYNEDGTVHVPKVVLLTDFVSNVF--------VAQYNTTLLPLLEFYEFSI 445

  Fly   685 TAPSNEVYIGIVESSSSASPADISSTVIANER---DLNMEMR-----RMNLVTLVLVAVGVIPLA 741
            .|.:.|.|.|.      .|...:.:..|.|:.   |.| |::     ..|:.|::.:.:|....|
 Worm   446 IAFTEEAYDGY------KSKLAMKAFQITNDEGYGDTN-ELKLCPKQGSNVTTIMFIIIGTCSGA 503

  Fly   742 AIILYLV-----RNFVIRR---RAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQ 798
            .:||.|:     :.::..|   |.|.|.|.|:                     ||.|..||
 Worm   504 MLILILLTVLYRQKYMWMRKLKRFKTSHVADI---------------------DDNDIFDH---- 543

  Fly   799 HMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEG 863
                                              :..:.||..:.:|             .||.|
 Worm   544 ----------------------------------WELSWDKLVVKNE-------------KLGHG 561

  Fly   864 NFGQVWK---------------AEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGSH 913
            .:|.|:|               |||.|.:....|.:::......|  |:...:.|..:|:.||.:
 Worm   562 AYGHVFKGKIVGVPPAIEKYNRAEALDYTDCDCAVKMLPKYATDA--AKQEFRHEIELMKNLGFN 624

  Fly   914 QNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPL--SPRTLAGF 976
            :::|.:||....|....|::|:.....||..::..:....|       .||:...  |.:....|
 Worm   625 EHLVNMLGCITVSAKSCLVLEHCCHRDLLRYVKNKKCDLEI-------SRSVDDTIDSHKEFLNF 682

  Fly   977 ALDIACGMEYIAGRRIVHRDLAARNVLL-DHNGM--CKICDFGMSIDLDAERMRKEQEKNAANDL 1038
            |..|..||.::..:||:||||||||:|: :..||  .|:.|||::|
 Worm   683 AWQITQGMRFLVDKRIIHRDLAARNILITEQCGMKSAKVSDFGLAI------------------- 728

  Fly  1039 MRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAP 1103
                                             .|:...:||..   |.|      .|||:|:|.
 Worm   729 ---------------------------------LSEPSENGEVT---GSD------RLPIKWLAL 751

  Fly  1104 ESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMS 1168
            |.|:...|:.::|:|:||||::|:.:||..|::::...|:|..:..|.||..|..:..:...:||
 Worm   752 ECLEKAEFSFKSDVWSFGIVIFEMYSLGDVPFAEIEPTELIAHLKSGARPKFPLLATDKIEEIMS 816

  Fly  1169 RCWHKEPHMRPSFAQ-SRLEITR 1190
            .||.::...||.|.: |:|..|:
 Worm   817 SCWSEKSEERPDFDELSKLFATQ 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	88/348 (25%)
F09G2.1	NP_001343836.1	PTKc	556..837	CDD:270623	91/363 (25%)