Protein Alignment Tie and B0252.1

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: NP_495419.2
• Gene: B0252.1 / 174133
• WormBaseID: WBGene00015087
• Length: 809
• Species: Caenorhabditis elegans
• Alignment Length: 867
• Identity: 178/867 - (20%)
• Similarity: 285/867 - (32%)
• Gaps: 245/867 - (28%)

  Fly   467 QTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEKP-- 529
            |.:|:...||:....:...|:..|...|.| :...||.:.|.|.|...........:|...|.
 Worm    16 QIKSQNIHPVLPPPTELSCPTVGTNAYILV-TVTPETDIRQFEDLLNSYGRLMPFNSTQQIKYDF 79

  Fly   530 --STTTSTSTTTTTPVPSTSK--RTTTNAPLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKA 590
              .:..||..||...:...|:  ..|...||...:..|.:.|:....|....|...|::....|.
 Worm    80 YFGSNYSTIVTTNDLIKEISEWFNDTNYYPLLYASALTPSASNKQYETEALVSIGKTILDNVAKD 144

  Fly   591 NS-----IIEKDKELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPRTQTQPSHTTDSSPKI 650
            |.     .::|...|:....|     :||.|     :|..|.::     .||.......|....:
 Worm   145 NQQVLTVYLKKQVVLLTDYAP-----LNITD-----IFNRNQNE-----NTQRLALSYADDLTPL 194

  Fly   651 LRTTVLTSIRSTVHPRPTSTSTTTSTTTTAP-PAV---TAPSNEVYI-----------GIVESSS 700
            .........:|......::|........... ||:   ..||::||:           .:|||:.
 Worm   195 EEAAEFPVFKSDDEMNLSATRNIFQENRDFEFPAIIHEDKPSSDVYVFMTSFNVSQLMRVVESTI 259

  Fly   701 SASPADISSTVIANERDLNMEMRRMNLVTLVLVAVG------------------VIP-LAAIILY 746
            :.....:|.|.:.::...:..::...:..::|..:|                  ..| ..|:...
 Worm   260 NGPTCQMSQTKMYSQFVHSQIIKNGTVWQIILPWLGQKTHSFSSNCLKSFNHMAAEPNCTAMKAQ 324

  Fly   747 LVRNFVIRRRAKQSEVF-------DVCITDQQPISPVKKVDS---KYQVDDD-----ED------ 790
            :..|||....|..::.|       ..|.|.....:.:|  ||   :..:|:|     ||
 Worm   325 IYANFVEHVAAANNQTFCYLFVGNAECATTTNLTTNIK--DSTHIRLVMDEDLNDVYEDFTLPLV 387

  Fly   791 -------EVDHQ-HHQHMQHHQNHQ---------------------------------------- 807
                   .||:| .|..|.:.||:.
 Worm   388 NLGFLDKTVDNQVIHNDMFYLQNYSTSCTDEIPMVPLLSARPWHRPKYLSIALDDMLTIFICATI 452

  Fly   808 ----------NHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRL--KSLL 860
                      .|.:.:|.|.:.:  .|:.......|....:...:|....:.:..|:.:  :.||
 Worm   453 SVTTFGILIYRHVSRKHRQQVEL--LSELMLQPRIYKAPKECAKVARLPWEIKSENVHIDKEFLL 515

  Fly   861 GEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQV------------SLKDEANIMRKLGSH 913
            |||....|:..:....|........|.:|..:.|:..|            .|:.|...||:|..|
 Worm   516 GEGTISNVYLGKLKGKSPIMQWIDRVEMKQYQDCAVAVRVPSHFDEPEEDQLQREIASMRQLRHH 580

  Fly   914 QNVVTLLG-------ACVESE-PHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSP 970
            .::..|||       .|...| .||.:::|      ||.:|......|        .....|:|.
 Worm   581 DHIALLLGWTNKNDLVCSLLELTHMNLIKY------LSQIRETAEQDN--------SSGFTPMSR 631

  Fly   971 ---RTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEK 1032
               :.|.....:|..|:|||..|.:|||||.||||||......||..||...:.|       ..|
 Worm   632 IPFQVLYKIIYEICDGIEYIHSRNLVHRDLTARNVLLTTGLRAKISGFGFCSEPD-------DPK 689

  Fly  1033 NAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALP 1097
            .|||.|            ..||                                         ||
 Worm   690 FAANSL------------ALRY-----------------------------------------LP 701

  Fly  1098 IRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVPQGLRPDLPKESRH 1161
            :||:|||.. ...|:.::|.|:||::::|:.:||..||..| ...|:|..:.:|..|..||....
 Worm   702 VRWLAPECF-IGKFSVKSDSWSFGVLMYEMFSLGEQPYEDLIRPEEIIESIRKGRVPAHPKYCSK 765

  Fly  1162 EFYNLMSRCWHKEPHMRPSFAQ 1183
            :.|.:|..|:......||:|.|
 Worm   766 QTYKIMQSCYQSFMSRRPNFTQ 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	91/354 (26%)
		PTKc	860..1187	CDD:270623	91/348 (26%)
B0252.1	NP_495419.2	PKc_like	515..792	CDD:389743	91/348 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900