DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and src-1

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001364829.1	Gene:	src-1 / 171722	WormBaseID:	WBGene00005077	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	122/481 - (25%)
Similarity:	189/481 - (39%)	Gaps:	156/481 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 FVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDED--EVDHQHHQHMQHHQNH--QNHQN 811
            |:||.|...:..|.:.|.|               .||..:  .|.|...:.:.|.|.:  ...:.
Worm   166 FLIREREADTREFALTIRD---------------TDDQRNGGTVKHYKIKRLDHDQGYFITTRRT 215

  Fly   812 HQHHQAM-------------------PMSQASQRDANHNRYGNNDDKTSLASEFHDFERSNIRLK 857
            .:..|.:                   |....::.|.:|:...|           .:..|:.:.||
Worm   216 FRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQN-----------WEIPRNQLHLK 269

  Fly   858 SLLGEGNFGQVWKAEADDLSGHFGATR---IVAVKTIR--ACSAQVSLKDEANIMRKLGSHQNVV 917
            ..||:||||:||          :|..|   .||:||::  ..|.:..|: ||.||::. .|.|:|
Worm   270 RKLGDGNFGEVW----------YGKWRGIVEVAIKTMKPGTMSPEAFLQ-EAQIMKQC-DHPNLV 322

  Fly   918 TLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIAC 982
            .|...|...||..:|.||.:.|.||..||...|...|                :.|...|..||.
Worm   323 KLYAVCTREEPFYIITEYMINGSLLQYLRTDGSTLGI----------------QALVDMAAQIAN 371

  Fly   983 GMEYIAGRRIVHRDLAARNVLLDHN----GMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNA 1043
            ||.|:..|::|||||||||||:...    .:.|:.|||:                 |..||..:.
Worm   372 GMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGL-----------------ARKLMEEDI 419

  Fly  1044 HKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQY 1108
            ::.:  .|:::                                          ||:|.|||:...
Worm   420 YEAR--TGAKF------------------------------------------PIKWTAPEAATC 440

  Fly  1109 HMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFY-NLMSRCWH 1172
            ..||.::|:|::||:|:||.|.|..||..:..|||:.:|..|.|..:|:....:.| .::.:||.
Worm   441 GNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWD 505

  Fly  1173 KEPHMRPSFAQSRLEITRSLHKWVDD 1198
            |.|..||:|        .:|:.:.||
Worm   506 KTPDRRPTF--------DTLYHFFDD 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	100/338 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	98/336 (29%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779
		SH2_Src_family	138..240	CDD:199827	14/88 (16%)
		PTKc_Src_like	270..522	CDD:270630	99/348 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010