DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Lyn

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001104566.1	Gene:	Lyn / 17096	MGIID:	96892	Length:	512	Species:	Mus musculus

Alignment Length:	344	Identity:	103/344 - (29%)
Similarity:	155/344 - (45%)	Gaps:	90/344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   848 DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR--ACSAQVSLKDEANIMRKL 910
            :..|.:|:|...||.|.||:||       .|::..:..|||||::  ..|.|..| :|||:|:.|
Mouse   241 EIPRESIKLVKKLGAGQFGEVW-------MGYYNNSTKVAVKTLKPGTMSVQAFL-EEANLMKTL 297

  Fly   911 GSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAG 975
             .|..:|.|.....:.||..:|.|:..:|.||..|:           |..||:.|.|    .|..
Mouse   298 -QHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLK-----------SDEGGKVLLP----KLID 346

  Fly   976 FALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMR 1040
            |:..||.||.||..:..:||||.|.|||:..:.||||.|||::      |:.::.|..|..
Mouse   347 FSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA------RVIEDNEYTARE---- 401

  Fly  1041 HNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPES 1105
                      |:::                                          ||:|.|||:
Mouse   402 ----------GAKF------------------------------------------PIKWTAPEA 414

  Fly  1106 LQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRC 1170
            :.:..||.::|:|:|||:|:||.|.|..||...|..:|:..:.||.|....:....|.|::|..|
Mouse   415 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMC 479

  Fly  1171 WHKEPHMRPSF--AQSRLE 1187
            |.::...||:|  .||.|:
Mouse   480 WKEKAEERPTFDYLQSVLD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	99/332 (30%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	99/330 (30%)
Lyn	NP_001104566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Lyn	67..122	CDD:212937
		SH2_Src_Lyn	125..225	CDD:198227
		PTKc_Lyn	239..510	CDD:270657	103/344 (30%)
		Pkinase_Tyr	247..497	CDD:285015	101/335 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010