DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and Lck

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001155904.1	Gene:	Lck / 16818	MGIID:	96756	Length:	520	Species:	Mus musculus

Alignment Length:	355	Identity:	103/355 - (29%)
Similarity:	154/355 - (43%)	Gaps:	95/355 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   851 RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS-AQVSLKDEANIMRKLGSHQ 914
            |..::|...||.|.||:||       .|::.....||||:::..| :..:...|||:|::| .|.
Mouse   253 RETLKLVERLGAGQFGEVW-------MGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL-QHP 309

  Fly   915 NVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRTLAGFALD 979
            .:|.|. |.|..||..:|.||...|.|:..|:            .|.|   ..|:...|...|..
Mouse   310 RLVRLY-AVVTQEPIYIITEYMENGSLVDFLK------------TPSG---IKLNVNKLLDMAAQ 358

  Fly   980 IACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAH 1044
            ||.||.:|..:..:||||.|.|:|:.....|||.|||::      |:.::.|..|..
Mouse   359 IAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLA------RLIEDNEYTARE-------- 409

  Fly  1045 KFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYH 1109
                  |:::                                          ||:|.|||::.|.
Mouse   410 ------GAKF------------------------------------------PIKWTAPEAINYG 426

  Fly  1110 MFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKE 1174
            .||.::|:|:|||:|.||.|.|..||..:|..|||:.:.:|.|...|.....|.|:||..||.:.
Mouse   427 TFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYHLMMLCWKER 491

  Fly  1175 PHMRPSFAQSRLEITRSLHKWVDDDSAASD 1204
            |..||:|     :..||:   :||...|::
Mouse   492 PEDRPTF-----DYLRSV---LDDFFTATE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	97/329 (29%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	96/327 (29%)
Lck	NP_001155904.1	SH3_Lck	76..129	CDD:212938
		SH2_Src_Lck	134..234	CDD:198225
		PTKc_Lck_Blk	248..511	CDD:270652	102/351 (29%)
		Pkinase_Tyr	256..505	CDD:285015	99/342 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010