DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tie and Kit

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	917	Identity:	205/917 - (22%)
Similarity:	329/917 - (35%)	Gaps:	280/917 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 PTAGLSDSIQDLKQTESEVAKPVVRRVVQK----VSPSSSTPLIITVLSAEEETTVGQTEALPTD 514
            |.||:  :|:::|:....:.   ||...|:    :.....|..:...:.|....:|.:|..|...
Mouse   167 PKAGI--TIKNVKRAYHRLC---VRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHLLKK 226

  Fly   515 ESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNA----PLSTTNTPTTTTSSTTP---- 571
            ..|.|  ...|.:..||:.::......|.|....:...|:    ..:.....|.|.||...
Mouse   227 GDTFT--VVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSG 289

  Fly   572 -----STTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNN--TSD 629
                 :..|..|.:.|   ||.|   ::||.             .|||....|..||..:  ..|
Mouse   290 VFMCYANNTFGSANVT---TTLK---VVEKG-------------FINISPVKNTTVFVTDGENVD 335

  Fly   630 CGVTPRTQTQPSH---------TTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVT 685
            ..|......:|.|         :.:.....:::...::||.....|.|....|...|.|
Mouse   336 LVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEGGTYT------ 394

  Fly   686 APSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRN 750
                     .:.|:|.|| |.::..|..|.:...:...|:....|..||.| .|...|..|....
Mouse   395 ---------FLVSNSDAS-ASVTFNVYVNTKPEILTYDRLINGMLQCVAEG-FPEPTIDWYFCTG 448

  Fly   751 FVIRRRAKQSEVFDVCITDQQPISP----VKKVD----SKYQVDDDEDEVDHQHHQHMQHHQNH- 806
                  |:|.     |.|   |:||    |:.|.    .|..|....|....:|:..::...::
Mouse   449 ------AEQR-----CTT---PVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASND 499

  Fly   807 --------------QNHQNHQHHQ--------------AM--------------PMSQASQR--- 826
                          .|.:..|.|.              ||              ||.:...:
Mouse   500 VGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGIIVMVLTYKYLQKPMYEVQWKVVE 564

  Fly   827 DANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG-----ATRIV 886
            :.|.|.|...|..........:|.|:.:.....||.|.||:|.:|.|      :|     |...|
Mouse   565 EINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATA------YGLIKSDAAMTV 623

  Fly   887 AVKTIRACSAQV----SLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRA 947
            |||.::. ||.:    :|..|..::..||:|.|:|.|||||....|.::|.||...|.||:.||.
Mouse   624 AVKMLKP-SAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRR 687

  Fly   948 ARSA---------------TNILPASVPG----------------------------------GR 963
            .|.:               .|:|.::.|.                                  .|
Mouse   688 KRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIER 752

  Fly   964 SLAP---------LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSI 1019
            .:.|         |....|..|:..:|.||.::|.:..:||||||||:||.|..:.||||||::.
Mouse   753 DVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLAR 817

  Fly  1020 DLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSH 1084
            |:          :|.:|.:::.||.
Mouse   818 DI----------RNDSNYVVKGNAR---------------------------------------- 832

  Fly  1085 HGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQL-TGREVIRRVP 1148
                       ||::||||||:...::|.|:|:|::||.|||:.:|||:||..: ...:..:.:.
Mouse   833 -----------LPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK 886

  Fly  1149 QGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSE 1213
            :|.|...|:.:..|.|::|..||..:|..||:|.|    :.:.:.|.: .||....|.:::..:.
Mouse   887 EGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQ----VVQLIEKQI-SDSTKHIYSNLANCNP 946

  Fly  1214 DLEHGVV 1220
            :.|:.||
Mouse   947 NPENPVV 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	106/396 (27%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	107/394 (27%)
Kit	NP_001116205.1	ig	217..308	CDD:278476	19/95 (20%)
		IG_like	221..310	CDD:214653	19/96 (20%)
		Ig4_SCFR	314..414	CDD:143268	23/128 (18%)
		IG_like	325..412	CDD:214653	19/102 (19%)
		Ig	427..501	CDD:299845	20/88 (23%)
		PTKc_Kit	556..930	CDD:270682	114/445 (26%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		1/1 (100%)
		Pkinase_Tyr	592..926	CDD:285015	107/405 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900