DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and Kdr

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_034742.2 Gene:Kdr / 16542 MGIID:96683 Length:1345 Species:Mus musculus


Alignment Length:1061 Identity:224/1061 - (21%)
Similarity:362/1061 - (34%) Gaps:384/1061 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   376 SVAQSTTPTITTTSTTPAPVSSTRPTASTRRPLTPVERSRSKYKYHMRE--------RGLV-PTA 431
            :||:....|:|..|.|.:........||:.|   .::|:|:..:.|.:.        :.|| .|.
Mouse   285 TVAKMFLSTLTIESVTKSDQGEYTCVASSGR---MIKRNRTFVRVHTKPFIAFGSGMKSLVEATV 346

  Fly   432 APPPAAP------PAPPVSRTRYVGSGRP-----TAGLSDSIQDLKQTESE-------VAKPV-- 476
            ......|      |||.:   ::..:|||     |..:.|.:..::.||.:       :..|:  
Mouse   347 GSQVRIPVKYLSYPAPDI---KWYRNGRPIESNYTMIVGDELTIMEVTERDAGNYTVILTNPISM 408

  Fly   477 -----VRRVVQKVSPSSSTPLIITVLSAEEETTV------------------------------G 506
                 :..:|..|.|......:|:.:.:.:..|:                              |
Mouse   409 EKQSHMVSLVVNVPPQIGEKALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPG 473

  Fly   507 QTEALPTDE------------STTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTN------ 553
            ||......|            ...|.:.....|..:.|.||.......|.:..|....|      
Mouse   474 QTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGE 538

  Fly   554 ---------APLSTTNTPTTTTSSTTPSTTTTSSTST----TVIPTTTKANSIIEKDKELIRALG 605
                     .|..|.......|...:.|...|:..:|    |.....::|.|:         .:|
Mouse   539 RVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSV---------HMG 594

  Fly   606 PALTREINIDDA---NNLIVFCNNTSDCGV----TPRTQTQPSHTTDSSPK------------IL 651
            .:||......||   .|..:|.|:|:|..:    ....|.|..:...:..|            |:
Mouse   595 ESLTPVCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRHCLVKQLII 659

  Fly   652 RTTVLTSIRSTVHPRPTSTSTTTSTTTTA----PPAVT-APSNEVYIGIVESSSSASPADISSTV 711
            ...:...|...:..:.|:...|...|..|    .|.:| ...||.   :||.|.          :
Mouse   660 LERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNET---LVEDSG----------I 711

  Fly   712 IANERDLNMEMRRM----------------------------------NLVTLVLVAVGVIPLAA 742
            :..:.:.|:.:||:                                  ||..::||...||   |
Mouse   712 VLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVIILVGTAVI---A 773

  Fly   743 IILYLVRNFVIR--RRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQN 805
            :..:|:...|:|  :||.:.|              :|.......:|.||                
Mouse   774 MFFWLLLVIVLRTVKRANEGE--------------LKTGYLSIVMDPDE---------------- 808

  Fly   806 HQNHQNHQHHQAMPMSQASQR---DANHNRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQ 867
                        :|:.:..:|   ||:.                .:|.|..::|...||.|.|||
Mouse   809 ------------LPLDERCERLPYDASK----------------WEFPRDRLKLGKPLGRGAFGQ 845

  Fly   868 VWKAEADDLSGHFG----AT-RIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACV 924
            |.:|:|      ||    || :.||||.::   ..|...:|..|..|:..:|.|.|||.|||||.
Mouse   846 VIEADA------FGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT 904

  Fly   925 E-SEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGR--------------------SLAPL 968
            : ..|.|:|:|:...|.|.:.||..|:  ..:|....|.|                    |:...
Mouse   905 KPGGPLMVIVEFCKFGNLSTYLRGKRN--EFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITSS 967

  Fly   969 SPRTLAGF-------------------------------ALDIACGMEYIAGRRIVHRDLAARNV 1002
            .....:||                               :..:|.|||::|.|:.:||||||||:
Mouse   968 QSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNI 1032

  Fly  1003 LLDHNGMCKICDFGMSIDL--DAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQ 1065
            ||....:.||||||::.|:  |.:.:||                                     
Mouse  1033 LLSEKNVVKICDFGLARDIYKDPDYVRK------------------------------------- 1060

  Fly  1066 GQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATL 1130
                         |:.:             ||::|||||::...::|.::|:|:||::||||.:|
Mouse  1061 -------------GDAR-------------LPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSL 1099

  Fly  1131 GSTPYSQL-TGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHK 1194
            |::||..: ...|..||:.:|.|...|..:..|.|..|..|||::|:.||||::....:...|..
Mouse  1100 GASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGNLLQA 1164

  Fly  1195 WVDDDSAASDYMDVSGFSEDL 1215
            ....|  ..||: |...||.|
Mouse  1165 NAQQD--GKDYI-VLPMSETL 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 111/391 (28%)
KdrNP_034742.2 Ig 226..327 CDD:472250 11/44 (25%)
Ig strand B 244..248 CDD:409353
Ig strand C 259..263 CDD:409353
Ig strand E 292..296 CDD:409353 1/3 (33%)
Ig strand F 306..311 CDD:409353 0/4 (0%)
Ig strand G 319..322 CDD:409353 1/2 (50%)
Ig 331..419 CDD:472250 15/90 (17%)
Ig strand B 350..354 CDD:409353 0/3 (0%)
Ig strand C 363..367 CDD:409353 0/6 (0%)
Ig strand E 383..387 CDD:409353 1/3 (33%)
Ig strand F 397..402 CDD:409353 0/4 (0%)
Ig strand G 412..415 CDD:409353 0/2 (0%)
Ig_3 549..642 CDD:464046 21/101 (21%)
I-set 665..742 CDD:400151 15/89 (17%)
Ig strand B 682..686 CDD:409353 0/3 (0%)
Ig strand C 695..699 CDD:409353 1/3 (33%)
Ig strand E 718..722 CDD:409353 1/3 (33%)
Ig strand F 732..737 CDD:409353 0/4 (0%)
VEGFR-2_TMD 757..791 CDD:375470 11/36 (31%)
PTKc_VEGFR2 824..1165 CDD:270681 114/427 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1272..1316
Blue background indicates that the domain is not in the aligned region.

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