Protein Alignment Tie and Fyn

DIOPT Version :9

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_030100741.1
• Gene: Fyn / 14360
• MGIID: 95602
• Length: 576
• Species: Mus musculus
• Alignment Length: 458
• Identity: 116/458 - (25%)
• Similarity: 175/458 - (38%)
• Gaps: 145/458 - (31%)

  Fly   786 DDDEDEVDHQHHQHMQHHQN-----------HQNHQNHQHHQAMPMSQASQRDAN---------H 830
            |.|:.:.||..|..::...|           ....|..||:        |:|.|.         |
Mouse   230 DWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY--------SERAAGLCCRLVVPCH 286

  Fly   831 NRYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIR-AC 894
            .......|.:....:..:..|.:::|...||.|.||:||       .|.:.....||:||:: ..
Mouse   287 KGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVW-------MGTWNGNTKVAIKTLKPGT 344

  Fly   895 SAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV 959
            .:..|..:||.||:|| .|..:|.|. |.|..||..::.||..:|.||..|:........||
Mouse   345 MSPESFLEEAQIMKKL-KHDKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKDGEGRALKLP--- 404

  Fly   960 PGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE 1024
                        .|...|..:|.||.||.....:||||.:.|:|:.:..:|||.|||::
Mouse   405 ------------NLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLA------ 451

  Fly  1025 RMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDT 1089
            |:.::.|..|..              |:::
Mouse   452 RLIEDNEYTARQ--------------GAKF----------------------------------- 467

  Fly  1090 IGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPD 1154
                   ||:|.|||:..|..||.::|:|:|||:|.|:.|.|..||..:..|||:.:|.:|.|..
Mouse   468 -------PIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMP 525

  Fly  1155 LPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFSEDLEHGV 1219
            .|::.....:.||..||.|:|..||:|                      :|:  .||.||
Mouse   526 CPQDCPISLHELMIHCWKKDPEERPTF----------------------EYL--QGFLED----- 561

  Fly  1220 VYF 1222
             ||
Mouse   562 -YF 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	94/329 (29%)
		PTKc	860..1187	CDD:270623	93/327 (28%)
Fyn	XP_030100741.1	SH3_Fyn_Yrk	124..179	CDD:212939
		SH2_Src_Fyn_isoform_a_like	184..284	CDD:198281	12/61 (20%)
		PTKc_Fyn	300..573	CDD:270655	102/380 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010