DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and CSF1R

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	NP_001275634.1	Gene:	CSF1R / 1436	HGNCID:	2433	Length:	972	Species:	Homo sapiens

Alignment Length:	437	Identity:	123/437 - (28%)
Similarity:	181/437 - (41%)	Gaps:	133/437 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 DKTSLA-SEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQV 898
            |.|.|. :|..:|.|:|::....||.|.||:|.:|.|..| |...|...||||.:::   ...:.
Human   565 DPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL-GKEDAVLKVAVKMLKSTAHADEKE 628

  Fly   899 SLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNIL-PASVPG- 961
            :|..|..||..||.|:|:|.|||||....|.::|.||...|.||:.||  |.|..:| |:..||
Human   629 ALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR--RKAEAMLGPSLSPGQ 691

  Fly   962 -------------------------------------------------------GRSLAPLSPR 971
                                                                   ||   ||..|
Human   692 DPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGR---PLELR 753

  Fly   972 TLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAAN 1036
            .|..|:..:|.||.::|.:..:|||:|||||||.:..:.||.|||::.|:          .|.:|
Human   754 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI----------MNDSN 808

  Fly  1037 DLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWM 1101
            .:::.||.                                                   ||::||
Human   809 YIVKGNAR---------------------------------------------------LPVKWM 822

  Fly  1102 APESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRPDLPKESRHEFYN 1165
            ||||:...::|.::|:|::||:||||.:||..|| ..|...:..:.|..|.:...|..:....|:
Human   823 APESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYS 887

  Fly  1166 LMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVSGFS 1212
            :|..||..||..||:|.|    |...|.:...:|....||.::...|
Human   888 IMQACWALEPTHRPTFQQ----ICSFLQEQAQEDRRERDYTNLPSSS 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	109/389 (28%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	110/387 (28%)
CSF1R	NP_001275634.1	IG_like	28..85	CDD:214653
		ig	207..293	CDD:365836
		Ig4_SCFR_like	299..400	CDD:319281
		Ig	416..495	CDD:319273
		Regulatory juxtamembrane domain	542..574		3/8 (38%)
		PTKc_CSF-1R	543..914	CDD:133237	119/419 (28%)
		Activation loop	796..818		8/82 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..950		3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810