DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Fgfr2

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_034337.2 Gene:Fgfr2 / 14183 MGIID:95523 Length:840 Species:Mus musculus


Alignment Length:966 Identity:211/966 - (21%)
Similarity:340/966 - (35%) Gaps:297/966 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   384 TITTTS---------TTPAPVSSTRPTAS-----TRRPLTPVERSRSKYKYHMRERGLVPTAAPP 434
            |:|..|         .|.|.:|..||:.|     |..|    |...:||:....|..:|   ||.
Mouse    17 TVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEP----EEPPTKYQISQPEAYVV---APG 74

  Fly   435 PA------APPAPPVSRTR---YVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSST 490
            .:      ...|..:|.|:   ::|....|..:.:.:|                 ::..:|..|.
Mouse    75 ESLELQCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQ-----------------IKGATPRDSG 122

  Fly   491 PLIITVLSAEEETT----VGQTEALPT--DESTTTTSTTTTTEKPSTTTSTSTTTT--------- 540
            ....|.....:..|    |..|:|:.:  ||..|.:|....:|..|...:...|.|         
Mouse   123 LYACTAARTVDSETWYFMVNVTDAISSGDDEDDTDSSEDVVSENRSNQRAPYWTNTEKMEKRLHA 187

  Fly   541 TPVPSTSKRTTTNAPLSTTNTPT---------------------------TTTSSTTPSTTTTSS 578
            .|..:|.|   ...|.....|||                           ....|..||   ...
Mouse   188 VPAANTVK---FRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPS---DKG 246

  Fly   579 TSTTVIPTT------TKANSIIEKD--KELIRALGPALTREINIDDANNLIVFCNNTSDCGVTPR 635
            ..|.::...      |....::|:.  :.:::|..||....:...|..   ..|...||  ..|.
Mouse   247 NYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVE---FVCKVYSD--AQPH 306

  Fly   636 TQ-------TQPSHTTDSSP--KILRTTVLTSIRSTV---HPRPTSTSTTTSTTTTAPPAVTAPS 688
            .|       ....:..|..|  |:|:...:.:....:   :.|..:.......|..|       .
Mouse   307 IQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLA-------G 364

  Fly   689 NEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVI 753
            |.:.|....:..:..||.:....|....|         .:.:.:..:||..:|.:::.::  |..
Mouse   365 NSIGISFHSAWLTVLPAPVREKEITASPD---------YLEIAIYCIGVFLIACMVVTVI--FCR 418

  Fly   754 RRRAKQSEVFDVCITDQQPI--SPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQ 816
            .:...:...|     ..||.  ...|::..:.||                               
Mouse   419 MKTTTKKPDF-----SSQPAVHKLTKRIPLRRQV------------------------------- 447

  Fly   817 AMPMSQASQRDANHN--------RYGNNDDKTSLA--SEFH-------DFERSNIRLKSLLGEGN 864
              .:|..|....|.|        |..:..|...||  ||:.       :|.|..:.|...||||.
Mouse   448 --TVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGC 510

  Fly   865 FGQVWKAEADDLSGHFGATRI-VAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVE 925
            ||||..|||..:........: ||||.::..:.:..|.|   |..:|:.:|.|:|::.|||||.:
Mouse   511 FGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 575

  Fly   926 SEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLA---------PLSPRTLAGFALDIA 981
            ..|..:|:|||.:|.|...|||.|          |.|...:         .::.:.|......:|
Mouse   576 DGPLYVIVEYASKGNLREYLRARR----------PPGMEYSYDINRVPEEQMTFKDLVSCTYQLA 630

  Fly   982 CGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKF 1046
            .||||:|.::.:||||||||||:..|.:.||.|||::.|::                        
Mouse   631 RGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN------------------------ 671

  Fly  1047 KFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMF 1111
            ..|:                             .||:.:|.        ||::|||||:|...::
Mouse   672 NIDY-----------------------------YKKTTNGR--------LPVKWMAPEALFDRVY 699

  Fly  1112 TTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPH 1176
            |.::|:|:||:::|||.|||.:||..:...|:.:.:.:|.|.|.|....:|.|.:|..|||..|.
Mouse   700 THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPS 764

  Fly  1177 MRPSFAQ---------------SRLEITRSLHKW---VDDDSAASDYMDVSGFSED 1214
            .||:|.|               ..|::|:.|.::   ..|..::....|.|.||.|
Mouse   765 QRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPD 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 105/341 (31%)
Fgfr2NP_034337.2 Ig 50..143 CDD:472250 20/116 (17%)
Ig strand B 77..81 CDD:409353 0/3 (0%)
Ig strand C 88..92 CDD:409353 1/3 (33%)
Ig strand E 109..113 CDD:409353 1/20 (5%)
Ig strand F 123..128 CDD:409353 0/4 (0%)
Ig strand G 136..139 CDD:409353 1/2 (50%)
IgI_2_FGFR 173..267 CDD:409443 14/99 (14%)
Ig strand A 173..176 CDD:409443 0/2 (0%)
Ig strand A' 184..189 CDD:409443 0/4 (0%)
Ig strand B 193..201 CDD:409443 3/10 (30%)
Ig strand C 207..212 CDD:409443 1/4 (25%)
Ig strand C' 215..217 CDD:409443 0/1 (0%)
Ig strand D 226..229 CDD:409443 0/2 (0%)
Ig strand E 233..238 CDD:409443 0/4 (0%)
Ig strand F 247..254 CDD:409443 1/6 (17%)
Ig strand G 257..267 CDD:409443 1/9 (11%)
IgI_3_FGFR2 275..379 CDD:409444 18/115 (16%)
Ig strand A 275..278 CDD:409444 0/2 (0%)
Ig strand A' 282..286 CDD:409444 2/3 (67%)
Ig strand B 294..301 CDD:409444 1/9 (11%)
Ig strand C 305..312 CDD:409444 2/6 (33%)
Ig strand D 327..332 CDD:409444 1/4 (25%)
Ig strand E 344..349 CDD:409444 0/4 (0%)
Ig strand F 357..365 CDD:409444 2/14 (14%)
Ig strand G 368..376 CDD:409444 1/7 (14%)
PTKc_FGFR2 475..787 CDD:270679 113/382 (30%)

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