DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tie and Fgfr1

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_034336.2 Gene:Fgfr1 / 14182 MGIID:95522 Length:822 Species:Mus musculus


Alignment Length:898 Identity:197/898 - (21%)
Similarity:337/898 - (37%) Gaps:265/898 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   430 TAAPPP-----AAPPAPPVS--------------RTRYVGSGRPTAGLSDSIQDLKQTESEVAKP 475
            ||.|.|     |.|...||.              |.|.....:....|.|.:|.::...:.:...
Mouse    20 TARPAPTLPEQAQPWGVPVEVESLLVHPGDLLQLRCRLRDDVQSINWLRDGVQLVESNRTRITGE 84

  Fly   476 VVRRVVQKVSPSSSTPLIITVLSAEEETT---VGQTEALPTDESTTTTSTTTTTEKPSTTTSTST 537
            .| .|...:...|.....:|...:..:||   |..::|||:.|.......:::.||.:..|..:.
Mouse    85 EV-EVRDSIPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNR 148

  Fly   538 TTTTPV---PSTSKRTTTNAPLSTTNTPTTTTSSTTPSTT------------------------T 575
            ....|.   |...::.....|.:.| ......||.||:.|                        |
Mouse   149 RPVAPYWTSPEKMEKKLHAVPAAKT-VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYAT 212

  Fly   576 TSSTSTTVIPTTTKAN------------------SIIEKD--KELIRALGPALTREINIDDANNL 620
            .|....:|:| :.|.|                  .::|:.  :.:::|..|| .:.:.:  .:|:
Mouse   213 WSIIMDSVVP-SDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPA-NKTVAL--GSNV 273

  Fly   621 IVFCNNTSDCGVTPRTQTQ-PSHT--------TDSSP--KILRTTVLTSI---RSTVHPRPTSTS 671
            ...|...||    |:...| ..|.        .|:.|  :||:|..:.:.   ...:|.|..|..
Mouse   274 EFMCKVYSD----PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE 334

  Fly   672 TTTSTTTTAPPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVG 736
            .....|..|..::....:..::.::|:... .||.::|.:               .:.:::...|
Mouse   335 DAGEYTCLAGNSIGLSHHSAWLTVLEALEE-RPAVMTSPL---------------YLEIIIYCTG 383

  Fly   737 VI----PLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHH 797
            ..    .|.::|:|.::                        |..||.|.                
Mouse   384 AFLISCMLGSVIIYKMK------------------------SGTKKSDF---------------- 408

  Fly   798 QHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGN-----------NDDKTSLASEFHDFE- 850
                    |.....|:..:::|:.:.....|:.:...|           :...|.:.:...::| 
Mouse   409 --------HSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYEL 465

  Fly   851 ---------RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI--VAVKTIRACSAQVSLKD-- 902
                     |..:.|...||||.||||..|||..|... ...|:  ||||.:::.:.:..|.|  
Mouse   466 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKD-KPNRVTKVAVKMLKSDATEKDLSDLI 529

  Fly   903 -EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASV-----PG 961
             |..:|:.:|.|:|::.|||||.:..|..:|:|||.:|.|...|:|.|      |..:     |.
Mouse   530 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARR------PPGLEYCYNPS 588

  Fly   962 GRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERM 1026
            ......||.:.|...|..:|.||||:|.::.:||||||||||:..:.:.||.|||::.|:     
Mouse   589 HNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI----- 648

  Fly  1027 RKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIG 1091
                          |:...:                                  ||:.:|.    
Mouse   649 --------------HHIDYY----------------------------------KKTTNGR---- 661

  Fly  1092 KRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLP 1156
                ||::|||||:|...::|.::|:|:||::||||.|||.:||..:...|:.:.:.:|.|.|.|
Mouse   662 ----LPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKP 722

  Fly  1157 KESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHKWVDDDSAASDYMDVS 1209
            ....:|.|.:|..|||..|..||:|.|...::.|.:..     ::..:|:|:|
Mouse   723 SNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL-----TSNQEYLDLS 770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 109/338 (32%)
PTKc 860..1187 CDD:270623 109/336 (32%)
Fgfr1NP_034336.2 Ig1_FGFR 40..118 CDD:143174 12/78 (15%)
IG_like 41..118 CDD:214653 12/77 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..162 9/41 (22%)
I-set 160..247 CDD:254352 13/88 (15%)
Heparin-binding 160..177 2/17 (12%)
Ig2_FGFR 163..247 CDD:143265 13/85 (15%)
IG_like 262..358 CDD:214653 19/102 (19%)
Ig3_FGFR 270..359 CDD:143175 17/92 (18%)
PTKc_FGFR1 464..765 CDD:270678 113/373 (30%)
Pkinase_Tyr 478..754 CDD:285015 110/343 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 782..822
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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