DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and Csf1r

DIOPT Version :10

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_001032948.2 Gene:Csf1r / 12978 MGIID:1339758 Length:977 Species:Mus musculus


Alignment Length:427 Identity:121/427 - (28%)
Similarity:178/427 - (41%) Gaps:135/427 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   832 RYGNND----DKTSLA-SEFHDFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTI 891
            ||..|.    |.|.|. :|..:|.|:|::....||.|.||:|.:|.|..| |...|...||||.:
Mouse   553 RYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGL-GKEDAVLKVAVKML 616

  Fly   892 RA---CSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATN 953
            ::   ...:.:|..|..||..||.|:|:|.|||||....|.::|.||...|.||:.||  |.|..
Mouse   617 KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR--RKAEA 679

  Fly   954 IL-PASVPGGRS--------------------------------LAPLSPRT------------- 972
            :| |:..||..|                                :.|:|..:             
Mouse   680 MLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEA 744

  Fly   973 --------LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKE 1029
                    |..|:..:|.||.::|.:..:|||:|||||||....:.||.|||::.|:        
Mouse   745 SRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDI-------- 801

  Fly  1030 QEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRH 1094
              .|.:|.:::.||.                                                  
Mouse   802 --MNDSNYVVKGNAR-------------------------------------------------- 814

  Fly  1095 ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPY-SQLTGREVIRRVPQGLRPDLPKE 1158
             ||::||||||:...::|.::|:|::||:||||.:||..|| ..|...:..:.|..|.:...|..
Mouse   815 -LPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVF 878

  Fly  1159 SRHEFYNLMSRCWHKEPHMRPSF--------AQSRLE 1187
            :....|::|..||..||..||:|        .|:|||
Mouse   879 APKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLE 915

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 107/394 (27%)
Csf1rNP_001032948.2 IG_like 28..101 CDD:214653
Ig strand B 38..42 CDD:409353
Ig strand E 67..71 CDD:409353
Ig strand F 81..86 CDD:409353
IG_like 113..195 CDD:214653
Ig 203..295 CDD:472250
Ig strand B 220..224 CDD:409353
Ig strand C 234..238 CDD:409353
Ig strand E 259..263 CDD:409353
Ig strand F 275..280 CDD:409353
Ig strand G 288..291 CDD:409353
Ig 299..398 CDD:472250
Ig strand B 319..323 CDD:409353
Ig strand C 333..337 CDD:409353
Ig strand E 362..366 CDD:409353
Ig strand F 376..381 CDD:409353
Ig strand G 389..392 CDD:409353
Ig_3 399..487 CDD:464046
Regulatory juxtamembrane domain. /evidence=ECO:0000250 540..572 6/18 (33%)
PTKc_CSF-1R 541..913 CDD:133237 118/423 (28%)
Activation loop. /evidence=ECO:0000250 794..816 8/82 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 921..957
Blue background indicates that the domain is not in the aligned region.

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