Protein Alignment Tie and tek

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_002934031.2
• Gene: tek / 100492432
• XenbaseID: XB-GENE-483684
• Length: 1127
• Species: Xenopus tropicalis
• Alignment Length: 1207
• Identity: 273/1207 - (22%)
• Similarity: 437/1207 - (36%)
• Gaps: 371/1207 - (30%)

  Fly   125 LNATAGDGESRNSAEIF---SPGDVDVVGDKPTTYRPSGANR--PSI--APLNSAQDRERKLMNV 182
            |..||..|:  |:..:|   :|.:.||:..|..|:..:....  |.:  ..|::.|.::..:..|
 Frog   129 LTVTASKGD--NTTLVFLKKNPIESDVLIYKNVTFYDTVPKHEVPHVLELTLSNVQPKDASVYRV 191

  Fly   183 LAARRTALHRGG--FRTRIGTTGRTAISPSAAVESTSKAPSDPRSVCIRNCTKNFTRRTTA---- 241
                   .:.||  |.|..                                |:...||.:|
 Frog   192 -------TYMGGNLFNTAF--------------------------------TRLIVRRCSAQNWG 217

  Fly   242 -SCMRQCANFTRMAMPSNGNSSVVLKGSASLKAAAPAGDRDTNEILFSDESSHGLFVVAKE---- 301
             .|...|:...        ||.|..:.:.  :...|.|...|...:..|::..|  |..||
 Frog   218 PQCKNNCSECQ--------NSGVCHEDTG--ECICPPGFMGTTCEMSCDDNKFG--VTCKESCKG 270

  Fly   302 QNGTLNH---IAD--GTKPAVMGKGIPSKTNSMEDDVEEEEDELKPYVYFG--AKLP-------- 351
            ..|..:|   :.|  |...|...||:..             ||:.|..::|  .||.
 Frog   271 NEGCKSHMFCLMDPYGCSCASGWKGLMC-------------DEVCPDGFYGPDCKLKCLCNKGTC 322

  Fly   352 --------PIRPGGLTIKAAEGDDDHPRVLEVSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPL 408
                    ||...||..:.....|..|.:||      |..|:.....|...:|    ..:|.:||
 Frog   323 HRFKGCICPIGWRGLHCENEGSADITPMILE------TEETLEMNIGTEFSLS----CKATGQPL 377

  Fly   409 TPVERSRSKYKYHMRERGLVPTAAPPPA------APPAPPVSRTRYVG----SGRPTAGLSDSIQ 463
             |:   :.::|. .|:.|.|..||....      |.....:.:.|:.|    |.:..||:::
 Frog   378 -PL---KQEFKL-FRQDGTVLQAASVTTKNKEVIALFKGEIIQQRHSGIWICSVKTVAGMAE--- 434

  Fly   464 DLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEETTVGQTEALPTDESTTTTSTTTTTEK 528
              |.....|..|.|.....|::.|.....||.| :|:.....|            ...:|....|
 Frog   435 --KHFNILVKVPPVALNSPKLNSSGPHYFIIEV-NADPYRGDG------------PVISTVLLYK 484

  Fly   529 PSTTTSTSTTTTTPV-----------PSTSKRT---------------------TTNAPLSTTNT 561
            ||..:::..|...|.           |:|..:.                     ||:.|...:..
 Frog   485 PSLISASWQTIEVPFNEKLIKLEGLEPNTEYKVCFQLRRQGEGGAGHPGPEAVLTTDPPCLPSPK 549

  Fly   562 PTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANNLIVFCNN 626
            .....|.:..|...|..|..    ...:.:.:.|.:...:........::::::....:|
 Frog   550 GLMLLSKSQYSLNLTWMTDF----KNNEEDRVYEVECSKVNTTVSLQNKKVSVNQGGIVI----- 605

  Fly   627 TSDCGVTPRT--QTQPSHTTDSSPKILRTTVLTSIRSTVHPRPTSTSTTTSTTTTAPPAVTAPSN 689
               .|:.|||  |.:....|:|..:.....:..:....:.|.|.:.:....|.::|
 Frog   606 ---DGLEPRTLYQCRVRENTNSQGEWSEMLLAWTHSDQIPPAPGNINIFNITDSSA--------- 658

  Fly   690 EVYIGIVESSSSASPADISSTVIAN-ERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVI 753
             |....||...|.|...|...:..| |.:.::::|.:.:|...|..     |.|...|||
 Frog   659 -VITWSVEEGHSISSIIIRYKIYGNTEYNHDIKIRNITIVHYQLKG-----LEANTPYLV----- 712

  Fly   754 RRRAKQSEVFDVCITD---QQPISPVKKVDSKYQVDDDEDEVDHQHHQH---------------- 799
                      ::|..:   |...:||:::.:       .:||...|...
 Frog   713 ----------EMCAENNIGQSFPNPVQELKT-------HEEVRGAHESKDGNMLLIAILGSAGMT 760

  Fly   800 ---------MQHHQNHQNHQNHQHHQAMPMSQASQRDANH--------------NRYGNNDDKTS 841
                     :.......|.||.       |:||.|.....              .:..||.|...
 Frog   761 CLTILLAFIIMLQLKRANFQNR-------MAQAFQNGVREEPVVQFNSGSLTQIRKAKNNPDPLE 818

  Fly   842 L-ASEFHDFERSNIRLKSLLGEGNFGQVWKA--EADDLSGHFGATRIVAVKTIRACSAQVSLKD- 902
            . ..|:||     |:.|.::||||||||.||  :.|      |.....|:|.::..:::...:|
 Frog   819 YPVLEWHD-----IKFKDVIGEGNFGQVLKARIKKD------GLRMDAAIKRMKEYASKDDHRDF 872

  Fly   903 --EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNIL---PASVPGG 962
              |..::.|||||.|::.|||||.......|.:|||..|.||..||.:|    :|   ||.....
 Frog   873 AGELEVLCKLGSHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR----VLETDPAFAIAN 933

  Fly   963 RSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMR 1027
            .:.:.||.:.|..||.|:|.||:|::.::.:||||||||:|:..|.:.||.|||:|
 Frog   934 STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS--------- 989

  Fly  1028 KEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGK 1092
            :.||.                     |:                         ||      |:|:
 Frog   990 RGQEV---------------------YV-------------------------KK------TMGR 1002

  Fly  1093 RHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPK 1157
               ||:||||.|||.|.::|:.:|:|:||::||||.:||.|||..||..|:..::|||.|.:.|.
 Frog  1003 ---LPVRWMAIESLNYSVYTSNSDVWSFGVLLWEIVSLGGTPYCGLTCAELYEKLPQGYRLEKPL 1064

  Fly  1158 ESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSLHK 1194
            ....|.|:||.:||.::|:.|||||:..:.:.|.|.:
 Frog  1065 NCDDEVYDLMRQCWREKPYERPSFAKIVVSLNRMLEE 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	118/336 (35%)
tek	XP_002934031.2	Ig_Tie2_1	25..118	CDD:463089
		Ig	349..439	CDD:472250	24/109 (22%)
		Ig strand B	366..370	CDD:409353	1/7 (14%)
		Ig strand C	382..386	CDD:409353	1/4 (25%)
		Ig strand E	407..411	CDD:409353	1/3 (33%)
		Ig strand F	421..426	CDD:409353	0/4 (0%)
		Ig strand G	434..437	CDD:409353	1/7 (14%)
		FN3	<469..528	CDD:473895	9/70 (13%)
		fn3	546..629	CDD:394996	13/94 (14%)
		FN3	642..733	CDD:238020	24/120 (20%)
		PTKc_Tie2	819..1121	CDD:133219	124/362 (34%)