DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tie and mylk5

DIOPT Version :9

Sequence 1:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster
Sequence 2:	XP_005164113.1	Gene:	mylk5 / 100003770	ZFINID:	ZDB-GENE-050309-74	Length:	856	Species:	Danio rerio

Alignment Length:	906	Identity:	167/906 - (18%)
Similarity:	283/906 - (31%)	Gaps:	286/906 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 VSVAQSTTPTITTTSTTPAPVSSTRPTASTRRPL--TPVERSRSKYKYHMRERGLVPTAAPPPAA 437
            :|.|...|..:   ||....:|..:|.....||:  .|.:.|.:....:...|.|.|.....|
Zfish     1 MSTADGKTRFV---STLRIQLSGFQPNGQGSRPVIKKPEDTSSAVNGNYNHTRQLDPPLFTKP-- 60

  Fly   438 PPAPPVSRTRYVGSGRPTAGLSDSIQDLKQTESEVAKPVVRRVVQKVSPSSSTPLIITVLSAEEE 502
                                |.|.|.|....           :....|.:.|.|:.|:.|...|.
Zfish    61 --------------------LEDCIVDEGND-----------ITLNGSITGSQPISISWLHNGET 94

  Fly   503 TTVGQT------------EALPTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTN-- 553
            ...|::            |.||.|..    :.|...|..:..||:|.........:..|...|
Zfish    95 VRFGKSSLVGEKVTLVVRECLPEDAG----AYTCMAENIAGKTSSSAAVCVRDYESIVRVNNNII 155

  Fly   554 --------APLSTTNTPTTTTSSTTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIR--ALGPAL 608
                    .|.....|...|:....|.:..|.|      |.|.  :.:::::..:.|  :.|...
Zfish   156 NKSHAHPHTPDLLNGTSEDTSVCKGPESPQTGS------PVTN--SPVLKREVHVKRRSSSGAGF 212

  Fly   609 TR------------EINIDDANNLIVFCNNTS---DCGVTPRTQTQPS-----HTTDSSPKILRT 653
            |.            |:.:.:...|..|...:|   .|.|..:.:.:.|     .:.|.:..::.:
Zfish   213 TAPPLQFVDPLDRLEVQVGETARLECFFKGSSPVASCWVFNKKEVEESSRFHLESCDENSSLVIS 277

  Fly   654 TVL--TSIRSTVHPRPTSTSTTTSTTTTA-----PPA------VTAPSNEV--YIGIVESSSSAS 703
            ..|  .|.|.|:..|...:|...:.|...     |||      |.:|.:.|  :.|......||.
Zfish   278 EALPEDSGRYTIFVRDRKSSAQHTVTLNVIDLPQPPASCPVARVLSPHSLVLSWSGPSYDGGSAV 342

  Fly   704 PADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCIT 768
            ...:.. |...|.:...|:......|.:.|..|:.|..        .:..|.||..:........
Zfish   343 TGYVVE-VCEKESEQWKELTAQCKSTSLRVTSGLQPQG--------QYCFRIRACNTVGVSEPSQ 398

  Fly   769 DQQPISPVKKVDSKYQ--VDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHN 831
            :.|.::.....||:.:  |:.....:|.||
Zfish   399 ESQTVTMDNPGDSREEKPVEYVNVTIDTQH----------------------------------- 428

  Fly   832 RYGNNDDKTSLASEFHDFERSNIRLKSLLGEGNFGQVW----KAEADDLSGHFGATRIVAVKTIR 892
                     .|...::..|:        ||.|.||||:    |....:.:|.|       .|:.|
Zfish   429 ---------KLTDHYNVLEK--------LGVGKFGQVFRMTHKVTGRECAGKF-------YKSRR 469

  Fly   893 ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLS-LLRAARSATNILP 956
            |...:.:.| |..:|..| .|..:|..|.|.......:::|||...|.|.. ::..:...|.:
Zfish   470 AKDREAARK-EIELMNFL-HHPKLVQCLAAYDNKAEMVMVMEYVAGGELFERIVDDSFEHTEV-- 530

  Fly   957 ASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVL-LDHNG-MCKICDFGMSI 1019
            :||               |:...|..|::|:..:.|:|.||...|:: :|..| ..||.|||::.
Zfish   531 SSV---------------GYMRQILEGIKYMHQQNILHLDLKPENIVCVDRTGSQIKIIDFGLAC 580

  Fly  1020 DLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSH 1084
            .||                                                      |:...|..
Zfish   581 KLD------------------------------------------------------PNTPLKVM 591

  Fly  1085 HGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQ 1149
            .|..          .::|||.:.:...|..||:|:.|::.: |...|.:|:...:..|.:..| .
Zfish   592 QGTP----------EFVAPEVINFEAVTLTTDMWSVGVICY-ILLSGESPFQGESDTETLALV-T 644

  Fly  1150 GLRPDLPKESRHEFYNL----MSRCWHKEPHMRPSFAQSRLEITRSLHKW-----VDDDSA 1201
            ..:.:..:||..|..::    :|...:|:|..|.|..::      ..|.|     ||:.|:
Zfish   645 AAQWEFDEESFEEITDMAKGFISSLLNKDPRRRLSCEEA------LAHDWLGFLCVDNSSS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	71/339 (21%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	71/337 (21%)
mylk5	XP_005164113.1	I-set	55..141	CDD:254352	21/122 (17%)
		Ig	72..137	CDD:143165	15/68 (22%)
		Ig	217..314	CDD:299845	16/96 (17%)
		I-set	218..306	CDD:254352	15/87 (17%)
		FN3	310..404	CDD:238020	20/102 (20%)
		S_TKc	434..689	CDD:214567	73/360 (20%)
		STKc_MLCK	440..689	CDD:271005	72/346 (21%)
		I-set	764..855	CDD:254352
		Ig	781..852	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4978
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050