Protein Alignment Tie and fgfr4

DIOPT Version :10

• Sequence 1: NP_523928.1
• Gene: Tie / 38559
• FlyBaseID: FBgn0014073
• Length: 1233
• Species: Drosophila melanogaster
• Sequence 2: XP_068071845.2
• Gene: fgfr4 / 100000160
• ZFINID: ZDB-GENE-980526-488
• Length: 923
• Species: Danio rerio
• Alignment Length: 542
• Identity: 150/542 - (27%)
• Similarity: 227/542 - (41%)
• Gaps: 155/542 - (28%)

  Fly   698 SSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPL--AAIILYLVRNFVIRRRAKQS 760
            |..||....:|...:|.|.|| ||.:   ...:::.|.|.:.|  |.:|:.|.|..|...|
Zfish   454 SHQSAWLTVLSEEDVAKEVDL-MEAK---YTDIIIYASGFLALVMAIVIVVLCRMQVHPSR---- 510

  Fly   761 EVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQ 825
            |.||..        ||:|: ||:.:              .:.:....|.........|.:::.|
Zfish   511 EPFDTL--------PVQKL-SKFPL--------------RRQYSVESNSSGKSSASLMRVARLS- 551

  Fly   826 RDANHNRYGNNDDKTSLAS--EFH-------DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG 881
                      :.....||.  ||.       :|.|.|:.|...||||.||||.:|||      :|
Zfish   552 ----------SSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEA------YG 600

  Fly   882 ATR-------IVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA 936
            ..:       .||||.::..:....|.|   |..:|:.:..|:|::.|||.|.:..|..:::|||
Zfish   601 INKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYA 665

  Fly   937 MRGRLLSLLRAARSATNILPASVPGGRSLA---------PLSPRTLAGFALDIACGMEYIAGRRI 992
            .:|.|...|||.|          |.|....         .|:.:.|...|..:|.||||:|.:|.
Zfish   666 SKGSLREYLRARR----------PPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRC 720

  Fly   993 VHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQ 1057
            :||||||||||:..:.:.||.|||::                      ...|:..:
Zfish   721 IHRDLAARNVLVTEDNVMKIADFGLA----------------------RGVHQIDY--------- 754

  Fly  1058 HWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGI 1122
                                  .||:.:|.        ||::|||||:|...::|.::|:|:||:
Zfish   755 ----------------------YKKTTNGR--------LPVKWMAPEALFDRVYTHQSDVWSFGV 789

  Fly  1123 VLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLE 1187
            ::|||.|||.:||..:...|:.:.:.:|.|.|.|....||.|..|..|||..|..||:|.|...|
Zfish   790 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEE 854

  Fly  1188 ITRSLHKWVDDDSAASDYMDVS 1209
            :.|.|      .|.:.:|:|:|
Zfish   855 LDRVL------VSISDEYLDLS 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	105/347 (30%)
fgfr4	XP_068071845.2	None