DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tie and fgfr4

DIOPT Version :9

Sequence 1:NP_523928.1 Gene:Tie / 38559 FlyBaseID:FBgn0014073 Length:1233 Species:Drosophila melanogaster
Sequence 2:NP_571505.1 Gene:fgfr4 / 100000160 ZFINID:ZDB-GENE-980526-488 Length:922 Species:Danio rerio


Alignment Length:542 Identity:149/542 - (27%)
Similarity:227/542 - (41%) Gaps:155/542 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   698 SSSSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPL--AAIILYLVRNFVIRRRAKQS 760
            |..||....:|...:|.|.|| ||.:   ...:::.|.|.:.|  |.:|:.|.|..|...|    
Zfish   453 SHQSAWLTVLSEEDVAKEVDL-MEAK---YTDIIIYASGFLALVMAIVIVVLCRMQVHPSR---- 509

  Fly   761 EVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQ 825
            |.||..        ||:|: ||:.:              .:.:....|.........|.:::.| 
Zfish   510 EPFDTL--------PVQKL-SKFPL--------------RRQYSVESNSSGKSSASLMRVARLS- 550

  Fly   826 RDANHNRYGNNDDKTSLAS--EFH-------DFERSNIRLKSLLGEGNFGQVWKAEADDLSGHFG 881
                      :.....||.  ||.       :|.|.|:.|...||||.||||.:|||      :|
Zfish   551 ----------SSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEA------YG 599

  Fly   882 ATR-------IVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYA 936
            ..:       .||||.::..:....|.|   |..:|:.:..|:|::.|||.|.:..|..:::|||
Zfish   600 INKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYA 664

  Fly   937 MRGRLLSLLRAARSATNILPASVPGGRSLA---------PLSPRTLAGFALDIACGMEYIAGRRI 992
            .:|.|...|||.|          |.|....         .|:.:.|...|..:|.||||:|.:|.
Zfish   665 SKGSLREYLRARR----------PPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRC 719

  Fly   993 VHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQ 1057
            :||||||||||:..:.:.||.|||::                      ...|:..:         
Zfish   720 IHRDLAARNVLVTEDNVMKIADFGLA----------------------RGVHQIDY--------- 753

  Fly  1058 HWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGI 1122
                                  .||:.:|.        :|::|||||:|...::|.::|:|:||:
Zfish   754 ----------------------YKKTTNGR--------MPVKWMAPEALFDRVYTHQSDVWSFGV 788

  Fly  1123 VLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLE 1187
            ::|||.|||.:||..:...|:.:.:.:|.|.|.|....||.|..|..|||..|..||:|.|...|
Zfish   789 LMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEE 853

  Fly  1188 ITRSLHKWVDDDSAASDYMDVS 1209
            :.|.|      .|.:.:|:|:|
Zfish   854 LDRVL------VSISDEYLDLS 869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TieNP_523928.1 TyrKc 854..1183 CDD:197581 104/347 (30%)
PTKc 860..1187 CDD:270623 104/345 (30%)
fgfr4NP_571505.1 IG_like 44..135 CDD:214653
Ig 52..136 CDD:299845
IG_like 150..224 CDD:214653
IGc2 156..212 CDD:197706
Ig2_FGFR 268..352 CDD:143265
IG_like 273..352 CDD:214653
IG_like 367..461 CDD:214653 3/7 (43%)
Ig3_FGFR-2 375..462 CDD:143266 3/8 (38%)
PTKc_FGFR4 565..877 CDD:133230 115/388 (30%)
Pkinase_Tyr 578..854 CDD:285015 105/352 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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