Protein Alignment NT1 and NT1

DIOPT Version :10

• Sequence 1: NP_729009.2
• Gene: NT1 / 38558
• FlyBaseID: FBgn0261526
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: XP_557166.4
• Gene: NT1 / 3290180
• VectorBaseID: AGAMI1_007382
• Length: 980
• Species: Anopheles gambiae
• Alignment Length: 1184
• Identity: 320/1184 - (27%)
• Similarity: 474/1184 - (40%)
• Gaps: 376/1184 - (31%)

  Fly    10 LFWALLYCVLYLDLVSGNSADDELMDFDFADSNDAAMEDWQL------DDLEEAKKAEQAEKK-- 66
            :.||.:  :|:.:..:..|.|..|.||:..|..|.|.:::..      ..::.:.|.....|.
Mosquito    13 VLWASV--LLHHNRAALASTDSGLPDFELDDGKDEADDEYYYVNDGTDQQMQPSHKIISYAKPPP 75

  Fly    67 ----------------LESNMLDFSVDLDEPEPEKQLPPFDWRERV--LRNALAKALADEGLRQK 113
                            :|.:...|.| :|:.:..:|.|..|::.:.  ::..:.||.|:...::|
Mosquito    76 PSAPDAGPLDASEPFLMEDDDTSFEV-IDDVDFVEQGPAMDFQRKAERMKRIMLKAFANREFQRK 139

  Fly   114 FAEVLPILRMLSSQQRLALSALISAQMNAKKGHELKFEQVRMMFGNEKKLLLPIVFDIANLIKSS 178
            |.||||:|:::|..|:..|:|||:||:|::.||.|..|||:.||||..:|:||:|:||||:|::.
Mosquito   140 FGEVLPLLKVMSKTQKSTLAALITAQVNSRDGHTLSLEQVKSMFGNRPELILPLVYDIANMIRTV 204

  Fly   179 TRKYINLGSDLASSALYH---TPINRREDDLTPEESQQDDQL--GTIAVEVEPK--KVSTEEVQL 236
            .:|          .:|.|   ..:::.:..|..:|....:.|  .:.::..||.  :::......
Mosquito   205 AKK----------ESLLHDQQEQLDQADKALVEDEGVLSNHLLRRSFSIRSEPHGFRMNDAAPPA 259

  Fly   237 ESLEDFFDEMGSEVLDPQMINEA---LTGDLHDNKTKTFKPENHGQRVRRSANEFVHKLTRSVPA 298
            ..|:|     |..::|.|...|.   .|....:|.|   :.|..|:..|.....|..||.:::|.
Mosquito   260 ADLKD-----GRLMVDDQDTAEVKIIATESTANNAT---QEETVGRSARSEPQPFFEKLVQALPR 316

  Fly   299 SVTEQ----QLLGGIAGRTIKLNTTAFQQPSSQEEEKMASSNG-----------GQS-------- 340
            ...:|    :....:.....|||.|||....||.::...:|:|           .||
Mosquito   317 FNVQQTHDKRSDDRMTYHERKLNMTAFNATGSQRDQLAMASDGPIPVTLPKVSPKQSRPVSSNAV 381

  Fly   341 ------------------------YSEVEDLAFAGLNGTEIPLSADERLDLQRNSAEETEEPLPS 381
                                    ..|:||||||||||||:        |....:|.
Mosquito   382 SVLPASTARPEAAPTSVTEEHKLTLEEIEDLAFAGLNGTEV--------DAYGGAAS-------- 430

  Fly   382 PEELIAGPRYRLGKRPLPGQ----KSGSPIKRKRVTSSLRGRPKTAASSHKPVVTPPNKKCERFT 442
                           .|||.    ..|.|:..|.:..  |.||....:      ..|::|||.|:
Mosquito   431 ---------------TLPGNGTSADGGGPVAEKLIGG--RQRPPALHT------LQPSEKCEHFS 472

  Fly   443 SNMCIRTDDYPLEQIMGSIRRHKNAMSALLAEFYDKPNNNLEFSDDFDDFSLS-----KKRREDE 502
            ..:|||..:||..:|:.||.||::|:.|||||:.||.|.......:.|:.:..     :||.:|.
Mosquito   473 GGVCIRVANYPTSEILYSITRHRHAIGALLAEYIDKANAQDRTVYEPDEIAQGINTKLRKREDDP 537

  Fly   503 GSAGG-MCQSVVRYARPQKAKSASGEWKYIVNTGQHTQTLRLEKCSNPVESCSYLAQTYRSHCSQ 566
            ..:|| ||.|::||||||||:||:||||||||||:|||||||||||.|.:||:||...:||.|.|
Mosquito   538 SKSGGSMCPSIIRYARPQKARSATGEWKYIVNTGEHTQTLRLEKCSTPQDSCTYLTDNFRSRCVQ 602

  Fly   567 VYNYHRLLSWDKVRGLHVDIFKVPTCCSCQVDGYRQQFPPLSSIQA-------KDYSPQSPVI-- 622
            :||||||||||..||||||||||||||||.:||||:.||||:|..:       :|.|..:..:
Mosquito   603 IYNYHRLLSWDAARGLHVDIFKVPTCCSCHIDGYRETFPPLTSYNSDFKSKIHEDPSESASTLIR 667

  Fly   623 --------NHSHNGYSTINEEDLDYAEESEEDELGLRYPSFNNRETNELYSSS------------ 667
                    .|.|:.|||:..:.:|  ||..||.:..::.:...|.....|..:
Mosquito   668 NTHSNHHQQHHHSHYSTLQFDQVD--EEEPEDNIAYQFSNGFQRIKPPKYEGALHLPAVPPPQPP 730

  Fly   668 ----------NKVRV----KLPGISSSVGP----------YLSPPDDDEDRYG-----GYKSSSS 703
                      .|.|.    |.|.||....|          |||||.:|. .||     |...::.
Mosquito   731 PPQGPVGAGLGKTRFERPPKHPAISKPKHPHFIAPPTLDTYLSPPPNDL-AYGIPFKRGPHYTNE 794

  Fly   704 SSKKYYSQVS--RRRPQHSEARLDLDLAPSETHSDQEVNLFAGPPNGGAEKPRIPLNRKRIYAST 766
            ::.|....|:  .|||....|.:......|...:|..:|..|..|.|  :...:|..:.:.....
Mosquito   795 NTLKRAGNVAGPNRRPLRKTATVQHHADQSIAETDSRLNQVAVLPPG--KMDLLPQTQAQNIIEK 857

  Fly   767 HTAPTTATSSASSSSVPSPAGGAAVRLRFPQTTSLPARTGTAALSPGSGFVSGFSASAGLSSASS 831
            |.                         |..|||:.|..|                   .|.....
Mosquito   858 HR-------------------------RRQQTTAQPPLT-------------------TLQQQQQ 878

  Fly   832 AHAAHAHQAGAIAPPGAPPTASPPSSPVNRQGGSKSRPRFYAPPATTTTNTAVVTGSASSLSTER 896
            ......| ...|:.|..|..|..|:.|::.|      |:   ||:|..|:|..||
Mosquito   879 QQQQQTH-IFRISQPSTPSMAVNPTVPLSTQ------PQ---PPSTAGTSTTTVT---------- 923

  Fly   897 TTQWERDQSTSLPQPPAVYPVSSIFPSGGGSEMSGKRINYNYHPIIDFFEKNRKAEAAATVSSIA 961
                                          |....:||||||||||||||:
Mosquito   924 ------------------------------STNGHQRINYNYHPIIDFFEE-------------- 944

  Fly   962 EESRIVEQRIFPQNSPKSQQNGMGLGMETITGVYQHPIPVPKTHERRMGYRAHNGGVGGAGAVGG 1026
                                       |.:..|.|..|.       |:|..:|
Mosquito   945 ---------------------------EEVPDVTQEQID-------RIGLNSH------------ 963

  Fly  1027 GAGFASDNAWLPMV 1040
                :|.|:|.|::
Mosquito   964 ----SSLNSWKPVI 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NT1	NP_729009.2	Spaetzle	508..595	CDD:465007	67/86 (78%)
NT1	XP_557166.4	None