DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT7 and krt7

DIOPT Version :9

Sequence 1:	NP_005547.3	Gene:	KRT7 / 3855	HGNCID:	6445	Length:	469	Species:	Homo sapiens
Sequence 2:	XP_002935788.2	Gene:	krt7 / 100101751	XenbaseID:	XB-GENE-876869	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	327/523 - (62%)
Similarity:	380/523 - (72%)	Gaps:	69/523 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     5 FSSPVFTSRSAAFSGRGA-------QVRLSSAR--PGGLG---------SSSL------------ 39
            |||    ||..:||.|.|       |:|:||.|  .||.|         ||||
Frog     3 FSS----SRQTSFSTRSAVPAASFSQMRISSTRSSSGGAGLGRAGGSFSSSSLSNIGGGVRKSVS 63

Human    40 YGLGASRPRVA-----------------VRSAYGGPV---GAGIREVTINQSLLAPLRLDADPSL 84
            ||:.:.|...|                 ..:.:||.|   |.||:||||||||||||.|:.||::
Frog    64 YGVSSGRSGGAGFGGAGFGGAGFGGAGFGGAGFGGGVAYSGPGIQEVTINQSLLAPLNLEIDPTI 128

Human    85 QRVRQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAGLR 149
            |.|||||.|||||||||||||||||||||||||:|||||.|||.|||||:|.:..:|:|.||.||
Frog   129 QHVRQEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQNQKSAKASNVGPLFDAYIANLR 193

Human   150 GQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMSKVELEAK 214
            .||:.|..|.|:||.|||:|||:|||||||||||||.||:|||||||||||||||||:|||||||
Frog   194 RQLDGLTGDKGKLEGELRNMQDLVEDFKNKYEDEINKRTSAENEFVVLKKDVDAAYMNKVELEAK 258

Human   215 VDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQYEEMAKCSRAEA 279
            ::||.|||||||.|.|.||.|||.|||||||||||||:|:||:|.||||||||||::|..|||.|
Frog   259 MEALTDEINFLRALYEAELRELQEQISDTSVVLSMDNNRALDMDSIIAEVKAQYEDIANKSRANA 323

Human   280 EAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKNQRAKLEAAIAEAEERGE 344
            ||.||.||:.|||.||:||||||.|:.||||:|||:|||||||:::|.|||||||.|||||||||
Frog   324 EAVYQNKFQELQATAGRHGDDLRTTKTEISELNRAMQRLQAEIESVKAQRAKLEAQIAEAEERGE 388

Human   345 LALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVG 409
            |||||||.|..|||||||:.|||||||||||||||:||||||||||||||||||||:|:: :|.|
Frog   389 LALKDARTKLAELEAALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEETRIS-EGPG 452

Human   410 AVNISVMNST----GGSSSGGGIGLTLG---------GTMGSNALSFSSSAGPGLLKAYSIRTAS 461
            .|::||:|||    ||||||.|.|...|         |..||::..|.|....| :|:||:.|:|
Frog   453 PVSVSVVNSTSSSMGGSSSGYGAGYGSGFGAGGSFSSGGFGSSSTKFGSGGSSG-VKSYSVTTSS 516

Human   462 ASR 464
            :||
Frog   517 SSR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT7	NP_005547.3	Keratin_2_head	1..87	CDD:292825	47/131 (36%)
		Head	2..90		49/134 (37%)
		DUF4081	<15..95	CDD:290051	48/129 (37%)
		Filament	90..402	CDD:278467	246/311 (79%)
		Coil 1A	90..126		32/35 (91%)
		Interaction with HPV16 E7. /evidence=ECO:0000269\|PubMed:12072504	92..97		3/4 (75%)
		Linker 1	127..144		8/16 (50%)
		Coil 1B	145..236		69/90 (77%)
		Linker 12	237..260		18/22 (82%)
		Coil 2	261..399		110/137 (80%)
		Tail	400..469		32/78 (41%)
krt7	XP_002935788.2	Keratin_2_head	<106..131	CDD:374433	18/24 (75%)
krt7	XP_002935788.2	Filament	134..446	CDD:365827	246/311 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4058
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43111
OrthoDB	1	1.010	-	-		D355615at33208
OrthoFinder	1	1.000	-	-		FOG0012580
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X62
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930