DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG15021 and MMP2

DIOPT Version :9

Sequence 1:NP_647902.1 Gene:CG15021 / 38546 FlyBaseID:FBgn0035544 Length:420 Species:Drosophila melanogaster
Sequence 2:NP_004521.1 Gene:MMP2 / 4313 HGNCID:7166 Length:660 Species:Homo sapiens


Alignment Length:38 Identity:11/38 - (28%)
Similarity:15/38 - (39%) Gaps:7/38 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   383 PAPTPEYGPPPPTSGGDEAGSLGPDGYNYNKPAKPFTF 420
            |.|....|.||.....|.|       :|::|..|.:.|
Human   553 PKPLTSLGLPPDVQRVDAA-------FNWSKNKKTYIF 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15021NP_647902.1 None
MMP2NP_004521.1 PG_binding_1 <70..97 CDD:307564
Cysteine switch. /evidence=ECO:0000250 100..107
Collagenase-like 1 110..221
Peptidase_M10 118..446 CDD:306839
Collagen-binding 222..396
FN2 226..274 CDD:128373
FN2 284..332 CDD:128373
FN2 342..390 CDD:128373
Collagenase-like 2 397..465
Required for inhibitor TIMP2 binding. /evidence=ECO:0000269|PubMed:1655733 414..660 11/38 (29%)
HX 466..660 CDD:238046 11/38 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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