DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15021 and MMP24

DIOPT Version :9

Sequence 1:	NP_647902.1	Gene:	CG15021 / 38546	FlyBaseID:	FBgn0035544	Length:	420	Species:	Drosophila melanogaster
Sequence 2:	NP_006681.1	Gene:	MMP24 / 10893	HGNCID:	7172	Length:	645	Species:	Homo sapiens

Alignment Length:	172	Identity:	46/172 - (26%)
Similarity:	56/172 - (32%)	Gaps:	49/172 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VALLLAAGVHADVSHLDTDLQEDGY--HYKQPSVPFPPPG--------------SGNGIEDS--- 53
            :.:..|:|.|.|.|..|   .|.|:  |     ..||.||              .||...|.
Human   220 IMIFFASGFHGDSSPFD---GEGGFLAH-----AYFPGPGIGGDTHFDSDEPWTLGNANHDGNDL 276

  Fly    54 ------------GIGPGPAPSA-PAPSYGPPQTRPPPPPPPPQPTPPAPRPSYGPPQTQPPRPPP 105
                        |:.....||| .||.|...:|.   ....||......:..||||  ..|..|.
Human   277 FLVAVHELGHALGLEHSSDPSAIMAPFYQYMETH---NFKLPQDDLQGIQKIYGPP--AEPLEPT 336

  Fly   106 QPTPSAPA----PPPPSYGPPQTPPPRPPPQPTPSAPAPPPS 143
            :|.|:.|.    .|.......|..|||||....||.|...|:
Human   337 RPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPN 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15021	NP_647902.1	None
MMP24	NP_006681.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		PG_binding_1	82..134	CDD:396175
		Cysteine switch. /evidence=ECO:0000250	137..144
		Peptidase_M10	162..327	CDD:395334	26/117 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		20/58 (34%)
		HX	377..569	CDD:238046	1/2 (50%)
		Hemopexin 1	377..425		1/2 (50%)
		Hemopexin 2	426..471
		Hemopexin 3	473..521
		Hemopexin 4	522..569
		DUF3377	575..645	CDD:403153
		PDZ-binding	643..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900