Protein Alignment nAChRbeta1 and HTR3B

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_006019.1
• Gene: HTR3B / 9177
• HGNCID: 5298
• Length: 441
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 107/520 - (20%)
• Similarity: 194/520 - (37%)
• Gaps: 127/520 - (24%)

  Fly     1 MESSCKSWLLCSILVLVAFSLVSASEDEE----RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAF 61
            |.||..:.|...|||............::    .|.:.|.:.|:|.:|||.|.|:...|...|..
Human     1 MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFV 65

  Fly    62 VQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEV 126
            ..:::|:.:|||:|::||.:.||.|..|.|:.:.:..|..:.||...:|.|||::....|..
Human    66 HAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIE--- 127

  Fly   127 RYKSNVLIY--PTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN 189
            ||.....:|  .:|.:....|....|:|:::...||||.|.|.:.|.|.....:.|.||...:..
Human   128 RYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPE 192

  Fly   190 FV--DLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISF 252
            .:  |...:.....|:::.|.:..::.:..:....:  |.|.:::||..|.|.|:|::|::.:..
Human   193 DIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQ--IQFNVVMRRHPLVYVVSLLIPSIFLML 255

  Fly   253 LCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVT 317
            :.:..||||.....::....|:|:...||.:.:|..:|.:....|||..:.........:|:..:
Human   256 VDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKS 320

  Fly   318 VIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPA 382
            ::::.                  |||             ...|...|.|.:
Human   321 IVLVK------------------FLH-------------DEQRGGQEQPFL-------------- 340

  Fly   383 ELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASK 447
                                                          |.|....:|...:.|.|.:
Human   341 ----------------------------------------------CLRGDTDADRPRVEPRAQR 359

  Fly   448 A--TEA-------------------VEFIAEHLRNEDLYIQTREDWKYVAMVIDRL--QLYIFFI 489
            |  ||:                   ::.|:.:|:.:|...|...:|..:....|||  |.|:|.:
Human   360 AVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFML 424

  Fly   490  489
            Human   425  424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	104/513 (20%)
		Neur_chan_LBD	28..236	CDD:280998	56/215 (26%)
		Neur_chan_memb	243..498	CDD:280999	41/270 (15%)
HTR3B	NP_006019.1	LIC	8..435	CDD:273305	104/513 (20%)
		Neur_chan_LBD	33..239	CDD:280998	56/210 (27%)
		Neur_chan_memb	246..>328	CDD:280999	17/99 (17%)
		HA-stretch	381..413		5/31 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810