DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and CHRNA6

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_004189.1 Gene:CHRNA6 / 8973 HGNCID:15963 Length:494 Species:Homo sapiens


Alignment Length:482 Identity:212/482 - (43%)
Similarity:303/482 - (62%) Gaps:40/482 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWD 92
            ||||...||..||:.||||:|::..|.|.|.:|..||.||:|.||||::|:|||.:|.||:|:||
Human    34 EERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWD 98

  Fly    93 EADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157
            ..:|.||..||:|.||:|||||||:|||.|:::|..|:..|:...|.:.|.||||::|||.:|:|
Human    99 PMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDIT 163

  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSNHPT 222
            :||||.|.|.:||||||::..::.|.:..:|  ||::|:|::..|:||:...|.:..:.:.....
Human   164 FFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEIIDASGYKHDIKYNCCEEI 226

  Fly   223 ETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSK 287
            .||||:...|||..:|||:|||:|.:.||||.|||||||::.||||||.||:||||.||||::::
Human   227 YTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITE 291

  Fly   288 ILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMK 352
            .:|.||||:||:.:|||||.|..|:||:|||.::|.::|.|.||.||.:::::||..||..|.|:
Human   292 TIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMR 356

  Fly   353 RP-RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRK 416
            .| .|||        |....|.|......||:        |...|..|...|.:..|  |   .|
Human   357 WPLDKTR--------GTGSDAVPRGLARRPAK--------GKLASHGEPRHLKECFH--C---HK 400

  Fly   417 VNSGGELGLGDGCRRES--------ESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWK 473
            .|.     |....||.|        |:|:.   |||......:|:||||::::.:...:..:|||
Human   401 SNE-----LATSKRRLSHQPLQWVVENSEH---SPEVEDVINSVQFIAENMKSHNETKEVEDDWK 457

  Fly   474 YVAMVIDRLQLYIFFIVTTAGTVGILM 500
            |||||:||:.|::|.||...||.|:.:
Human   458 YVAMVVDRVFLWVFIIVCVFGTAGLFL 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 212/480 (44%)
Neur_chan_LBD 28..236 CDD:280998 98/207 (47%)
Neur_chan_memb 243..498 CDD:280999 109/263 (41%)
CHRNA6NP_004189.1 Neur_chan_LBD 34..484 CDD:332142 212/480 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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