DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and Chrna6

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_476532.2 Gene:Chrna6 / 81721 RGDID:69281 Length:493 Species:Rattus norvegicus


Alignment Length:494 Identity:206/494 - (41%)
Similarity:312/494 - (63%) Gaps:28/494 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 WLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72
            | :|..|.....|....|  ||:|...||..||:.||||:|::..|.|.|.||..||.||:|.||
  Rat    17 W-ICGFLAFFKGSRGCVS--EEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQ 78

  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137
            ||::|:|||.||.||:|.||..:|.||..||:|.|.:|||||||:|||.|:::|..|:..|:...
  Rat    79 IMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYD 143

  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202
            |.:.|.||||::|||.:|:|:||||.|.|.:||||||::..::.|.:..:|  ||::|:|::..|
  Rat   144 GVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEW 206

  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267
            :|::...|.:..:.:......||||:...|||..:|||:|||:|.:.||||.|||||||::.|||
  Rat   207 EIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEK 271

  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332
            |||.||:||||.||||::::.:|.||||:||:.:|||||.|..|:||:|||.::|.::|.|.||.
  Rat   272 VTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHT 336

  Fly   333 MPMYIRSIFLHYLPAFLFMKRP-RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQS 396
            ||.:::::||...|:.|.|:|| .||:     |..|:..|.       :..:.|..:.....|:.
  Rat   337 MPKWVKTMFLQVFPSILMMRRPLDKTK-----EADGVKDPK-------THTKRPAKVKFTHRKEP 389

  Fly   397 KMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRN 461
            |:    |.:..|  |..:.::..|..|. ....:..:|:|:.   .|:.....::|:||.|::::
  Rat   390 KL----LKECRH--CHKSSEIAPGKRLS-QQPAQWVAENSEH---PPDVEDVIDSVQFITENMKS 444

  Fly   462 EDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500
            .:...:..:||||:|||:||:.|::|.||...||||:.:
  Rat   445 HNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL 483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 206/492 (42%)
Neur_chan_LBD 28..236 CDD:280998 97/207 (47%)
Neur_chan_memb 243..498 CDD:280999 99/255 (39%)
Chrna6NP_476532.2 LIC 34..483 CDD:273305 201/472 (43%)
LGIC_ECD 34..240 CDD:355788 97/207 (47%)
Cys-loop 158..172 CDD:349787 8/13 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.920

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