Protein Alignment nAChRbeta1 and LOC798522

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_001338964.6
• Gene: LOC798522 / 798522
• -ID: -
• Length: 488
• Species: Danio rerio
• Alignment Length: 519
• Identity: 170/519 - (32%)
• Similarity: 275/519 - (52%)
• Gaps: 62/519 - (11%)

  Fly     6 KSWLLCSILVLVAFSLVSASEDEE-----RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLI 65
            :.|:  .:::|.|..|..||...:     :|:.||...|:..:|||.:..:.:.|...:...|:.
Zfish     5 RRWM--EVMLLSALLLAEASHCAQGRFAHKLLNDLMEDYSSALRPVDDTDKSLNVTLQVTLSQIK 67

  Fly    66 NVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKS 130
            :::|:||::.:.:|:|.||:|..|:|.:.||.|:.|:|:|...:|:||:||:|.||.::.....:
Zfish    68 DMDERNQVLIAYLWIRQVWHDAHLKWSKEDYDGLEVIRIPSSLIWRPDLVLYNKADDDFSGPVDT 132

  Fly   131 NVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD 195
            ||::..|||:.|..|||.:|||.:||:|||||.|.|.:.|||||:||:||.:|:.:...  ||||
Zfish   133 NVVLRYTGEITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIAMGSVSG--DLSD 195

  Fly   196 YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
            :.::..|:...:||..||...........|||:.::::|::.||.:||:||..|||||..|.|||
Zfish   196 FVENVEWECHGMPATKNVIMYGCCSDPYPDITYTVLLQRRSSFYIINLLLPCFLISFLAPLSFYL 260

  Fly   261 PAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            ||::||||:||:::||:|.||.::|::.:||:..| ||||||.:.|..|.|.|..:|:.|:|.:|
Zfish   261 PADSGEKVSLGVTVLLALTVFQMMVAESMPPSESV-PLIAKYYIATMTMITASTALTIFIMNIHF 324

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMP---AHPHPSYGSPAELPKH 387
            .|.....:|.:.:.:.:.|:....|:....::          .:.|   |....|:.|.....||
Zfish   325 CGAEAKPVPYWAKVLIIDYMSKIFFVYEVGES----------CASPFGQAEESESFHSQNHHRKH 379

  Fly   388 ISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEA------- 445
                             .||||..||:         |....|..|...|..:|.....
Zfish   380 -----------------KLHHPKGKIS---------GSPPPCCPEDHKSPFVLGCESCVYCGFRS 418

  Fly   446 ------SKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAP 503
                  :|....||:||...|.:........:||.||.|:||..::||||:....::.|:..||
Zfish   419 GNLACDTKLLRNVEYIANCFREQKTTALKVAEWKKVAKVMDRFFMWIFFIMVFLMSILIIGKAP 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	168/512 (33%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	77/213 (36%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
LOC798522	XP_001338964.6	LGIC_ECD	30..236	CDD:475126	77/207 (37%)
		LIC	32..477	CDD:455710	161/483 (33%)