DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta1 and Chrna1

DIOPT Version :9

Sequence 1:NP_523927.2 Gene:nAChRbeta1 / 38545 FlyBaseID:FBgn0000038 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_077811.1 Gene:Chrna1 / 79557 RGDID:69277 Length:457 Species:Rattus norvegicus


Alignment Length:532 Identity:191/532 - (35%)
Similarity:292/532 - (54%) Gaps:101/532 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LCSILVLVAF---SLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            |.::|:|:..   ..|..||.|.|||..||:.|:.::|||.:..:.|.|..||..:|||||:|.|
  Rat     3 LTAVLLLLGLCSAGTVLGSEHETRLVAKLFKDYSSVVRPVGDHREIVQVTVGLQLIQLINVDEVN 67

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            ||:.:||.|:..|.||.|:|:..||||:..:.:|.:|:|:||:||:|||||::.:...:.||:..
  Rat    68 QIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDY 132

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            ||.:.|.||||::|.|.|.||:||||:|.|.||.|:||::|..|  |:....:..|||::.:||.
  Rat   133 TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV--AINPESDQPDLSNFMESGE 195

  Fly   202 WDIIEVPAYLN--VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            |.|.|...:.:  .|....|.| ..|||::.:::|..|::.||:|:|.:|.|||..||||||.::
  Rat   196 WVIKEARGWKHWVFYSCCPNTP-YLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDS 259

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||:||.||:||||.||||::.:::|.||..:|||.||:|||.:....||::|||:||.:.|.|.
  Rat   260 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS 324

  Fly   330 THRMPMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI 391
            ||.||.::|.:|:..:|..:|   ||||.:                                   
  Rat   325 THIMPEWVRKVFIDTIPNIMFFSTMKRPSR----------------------------------- 354

  Fly   392 GGKQSK---MEVMELSDL-----------HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLS 442
             .||.|   .|.:::||:           |.|                             ::..
  Rat   355 -DKQEKRIFTEDIDISDISGKPGPPPMGFHSP-----------------------------LIKH 389

  Fly   443 PEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            ||...|.|.|::|||.::::.......|:|||||||:|.:.|.:|.:|...||:.:.        
  Rat   390 PEVKSAIEGVKYIAETMKSDQESNNASEEWKYVAMVMDHILLGVFMLVCLIGTLAVF-------- 446

  Fly   508 YVDQDRIIEIYR 519
               ..|:||:::
  Rat   447 ---AGRLIELHQ 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta1NP_523927.2 LIC 8..500 CDD:273305 188/511 (37%)
Neur_chan_LBD 28..236 CDD:280998 90/209 (43%)
Neur_chan_memb 243..498 CDD:280999 89/271 (33%)
Chrna1NP_077811.1 LIC 21..447 CDD:273305 184/504 (37%)
Neur_chan_LBD 24..231 CDD:280998 90/209 (43%)
Neur_chan_memb 238..446 CDD:280999 89/272 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18945
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
65.880

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