Protein Alignment nAChRbeta1 and Chrna1

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_077811.1
• Gene: Chrna1 / 79557
• RGDID: 69277
• Length: 457
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 191/532 - (35%)
• Similarity: 292/532 - (54%)
• Gaps: 101/532 - (18%)

  Fly    10 LCSILVLVAF---SLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            |.::|:|:..   ..|..||.|.|||..||:.|:.::|||.:..:.|.|..||..:|||||:|.|
  Rat     3 LTAVLLLLGLCSAGTVLGSEHETRLVAKLFKDYSSVVRPVGDHREIVQVTVGLQLIQLINVDEVN 67

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136
            ||:.:||.|:..|.||.|:|:..||||:..:.:|.:|:|:||:||:|||||::.:...:.||:..
  Rat    68 QIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDY 132

  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201
            ||.:.|.||||::|.|.|.||:||||:|.|.||.|:||::|..|  |:....:..|||::.:||.
  Rat   133 TGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV--AINPESDQPDLSNFMESGE 195

  Fly   202 WDIIEVPAYLN--VYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA 264
            |.|.|...:.:  .|....|.| ..|||::.:::|..|::.||:|:|.:|.|||..||||||.::
  Rat   196 WVIKEARGWKHWVFYSCCPNTP-YLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDS 259

  Fly   265 GEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPR 329
            |||:||.||:||||.||||::.:::|.||..:|||.||:|||.:....||::|||:||.:.|.|.
  Rat   260 GEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPS 324

  Fly   330 THRMPMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAI 391
            ||.||.::|.:|:..:|..:|   ||||.:
  Rat   325 THIMPEWVRKVFIDTIPNIMFFSTMKRPSR----------------------------------- 354

  Fly   392 GGKQSK---MEVMELSDL-----------HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLS 442
             .||.|   .|.:::||:           |.|                             ::..
  Rat   355 -DKQEKRIFTEDIDISDISGKPGPPPMGFHSP-----------------------------LIKH 389

  Fly   443 PEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFE 507
            ||...|.|.|::|||.::::.......|:|||||||:|.:.|.:|.:|...||:.:.
  Rat   390 PEVKSAIEGVKYIAETMKSDQESNNASEEWKYVAMVMDHILLGVFMLVCLIGTLAVF-------- 446

  Fly   508 YVDQDRIIEIYR 519
               ..|:||:::
  Rat   447 ---AGRLIELHQ 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	188/511 (37%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	90/210 (43%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)
Chrna1	NP_077811.1	LIC	21..447	CDD:455710	184/504 (37%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	91/211 (43%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)