Protein Alignment nAChRbeta1 and chrnb3a

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_957514.1
• Gene: chrnb3a / 794401
• ZFINID: ZDB-GENE-040108-1
• Length: 467
• Species: Danio rerio
• Alignment Length: 510
• Identity: 201/510 - (39%)
• Similarity: 298/510 - (58%)
• Gaps: 61/510 - (11%)

  Fly     9 LLCSILVLVAFS----------LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQ 63
            |..|.::|||.:          .||.:|.|:.|:|:|||||.|.:|||.:....:.|||||...|
Zfish     3 LQISGILLVAAAAYATIEAPEEFVSLAEMEDTLLRNLFRGYQKWVRPVLHANDTITVRFGLKISQ 67

  Fly    64 LINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRY 128
            |::|:||||:|.:||||...|.||:|:|:..|||||..:|:|.:.:|.|||||:.||||.:|...
Zfish    68 LVDVDEKNQLMTTNVWLWEEWTDYKLRWNPEDYGGITSIRVPSETIWLPDIVLYENADGRFEGSL 132

  Fly   129 KSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDL 193
            .:..::...|.::|.|||.|:|:||:|||:||||:|.|.|||||||::|..|.|.|.:  .:||.
Zfish   133 MTKAIVRFNGTIMWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLTLVD--AYVDR 195

  Fly   194 SDYWKSGTWDIIEVPAYL-NVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLV 257
            .|::.:|.|:|:...... :..:|..::|.   :|:..|::|..||||:.||:|.:.:|||.|||
Zfish   196 KDFFDNGEWEILNATGQRGSRRDGIYSYPY---LTYSFILKRLPLFYTLFLIIPCLGLSFLTVLV 257

  Fly   258 FYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIIN 322
            ||||::.|||::|..|:|:||.||||::.:|:|.:|.|:|||.:||||..|..|.||:|||.:||
Zfish   258 FYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTFSIIVTVFVIN 322

  Fly   323 WNFRGPRT-HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPK 386
            .:.|...| |.|..:::|:||..||..|.| |....|.:            :|.....|| ||.:
Zfish   323 VHHRSSATYHPMAPWVKSLFLQRLPRLLCM-RGHTDRYQ------------YPDIELRSP-ELKR 373

  Fly   387 HISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEA 451
                 |.|:.:                 :|...||..|:     :|.|:...|.|   ..|||.:
Zfish   374 -----GMKKGQ-----------------QKSAGGGRAGV-----KEDENQAWIAL---LEKATHS 408

  Fly   452 VEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIF 506
            |.:|:.|:|.|....:..:|||:||.|:||:.|:.|..|:..||:.|...|..:|
Zfish   409 VHYISRHIRKEHFIREVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFTPALQMF 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	199/502 (40%)
		Neur_chan_LBD	28..236	CDD:280998	92/208 (44%)
		Neur_chan_memb	243..498	CDD:280999	94/255 (37%)
chrnb3a	NP_957514.1	LIC	9..459	CDD:273305	197/498 (40%)
		Neur_chan_LBD	32..236	CDD:280998	92/208 (44%)
		Neur_chan_memb	243..456	CDD:280999	94/256 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820