Protein Alignment nAChRbeta1 and Htr3a

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_006243083.1
• Gene: Htr3a / 79246
• RGDID: 61818
• Length: 488
• Species: Rattus norvegicus
• Alignment Length: 528
• Identity: 138/528 - (26%)
• Similarity: 239/528 - (45%)
• Gaps: 89/528 - (16%)

  Fly    10 LCSILVLVAF---SLVSASEDEER------------LVR---DLFRGYNKLIRPVQNMTQKVGVR 56
            ||...||:|.   .|::..|...|            |:|   .|...|.|.:|||::..:...|.
  Rat     3 LCIPQVLLALFLSVLIAQGEGSRRRATQAHSTTQPALLRLSDHLLANYKKGVRPVRDWRKPTLVS 67

  Fly    57 FGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVL--FNN 119
            ..:....::||:||||::.:.:|.|..|.|..|||...|:..:..|.:|.|.:|.|||::  |.:
  Rat    68 IDVIMYAILNVDEKNQVLTTYIWYRQFWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVD 132

  Fly   120 ADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL 184
            ...:..:.|   |.::..|||....|....::|::|:..||||.|.|.:.|.||......::::|
  Rat   133 VGKSPSIPY---VYVHHQGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL 194

  Fly   185 YNNKNFV--DLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPT 247
            :.....|  |.|.:...|.|:::.|......:..:::: :..::.||::|||:.|||.|:|:||:
  Rat   195 WRTPEEVRSDKSIFINQGEWELLGVFTKFQEFSIETSN-SYAEMKFYVVIRRRPLFYAVSLLLPS 258

  Fly   248 VLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTV 312
            :.:..:.::.|.||.::||:|:..|::||...|||::||..||.|::..|||..|.:....:..:
  Rat   259 IFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVI 323

  Fly   313 SILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPS 377
            |:..|:.|:....:......:|.::|.:.|              .|:.|::.:....|...|..:
  Rat   324 SLAETIFIVQLVHKQDLQRPVPDWLRHLVL--------------DRIAWLLCLGEQPMAHRPPAT 374

  Fly   378 Y---------GS--PAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRR 431
            :         ||  || :..|.|.:|..|         ||                       .:
  Rat   375 FQANKTDDCSGSLLPA-MGNHCSHVGSPQ---------DL-----------------------EK 406

  Fly   432 ESESSDSILLSP-EASKAT----EAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVT 491
            .|.|.||.|..| |||.|.    :.:..|...|...|...:...||..|..|:|||...|:.:..
  Rat   407 TSRSRDSPLPPPREASLAVRGLLQELSSIRHSLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAV 471

  Fly   492 TAGTVGIL 499
            .|.::.::
  Rat   472 LAYSITLV 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	138/528 (26%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	61/227 (27%)
		Cys-loop	152..166	CDD:349833	7/13 (54%)
Htr3a	XP_006243083.1	LIC	5..482	CDD:273305	136/526 (26%)