Protein Alignment nAChRbeta1 and chrna2a

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001035417.1
• Gene: chrna2a / 678575
• ZFINID: ZDB-GENE-040108-2
• Length: 520
• Species: Danio rerio
• Alignment Length: 523
• Identity: 228/523 - (43%)
• Similarity: 317/523 - (60%)
• Gaps: 54/523 - (10%)

  Fly     8 WLLCSILVLVAFSLVSASED-------EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLI 65
            |:    |:|:|..:.....|       |::|...||.||||..|||:|::..|.|:|||:..|||
Zfish    14 WM----LILIADHVQPVLSDGWIHAHAEDKLFHKLFIGYNKWSRPVRNISDVVIVKFGLSIAQLI 74

  Fly    66 NVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKS 130
            :|:||||:|.:||||:..|.||:|:|:.:::..:..:|:|.:.:|.|||||:|||||.:.|.:.:
Zfish    75 DVDEKNQMMTTNVWLKQEWNDYKLRWNPSEFDNVTSIRVPSEMIWVPDIVLYNNADGEFAVTHMT 139

  Fly   131 NVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSD 195
            ...::.||:|.|||||||:|||:||||:||||||.|.|||||||:  |:..:.|...:..|||.|
Zfish   140 KAHLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTY--DKAKIDLEQIEGTVDLKD 202

  Fly   196 YWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYL 260
            ||:||.|.||......|..:.|..|....|||::.||||..||||:|||:|.:|||.|.||||||
Zfish   203 YWESGEWAIINAVGTYNTKKYDCCHEIYPDITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYL 267

  Fly   261 PAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNF 325
            |::.|||:||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.
Zfish   268 PSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHH 332

  Fly   326 RGPRTHRMPMYIRSIFLHYLPAFLFMKRPR-----------KTRLRWMMEMPG--------MSMP 371
            |.|.||.||.::.|:||.::|.:|||:||.           .|...|..:..|        |...
Zfish   333 RSPSTHSMPRWVHSVFLDHIPRWLFMRRPEPEKKPKKTANLSTSKSWFQQETGVDGLVCQDMEFG 397

  Fly   372 AHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDL----HHPNCKINRKVNSGGELGLGDGCRRE 432
            .....|..||:....|:|.......|.|:..|..:    .|| .|:...|:..|
Zfish   398 IGLSTSISSPSATSLHLSDSEPLLQKYELQHLGHVVNLCQHP-AKLGNLVSEPG----------- 450

  Fly   433 SESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVG 497
                  :|.||...:|.|.|.:||:|||.||.....:||||||||||||:.|::|.||...||:|
Zfish   451 ------LLFSPCVLRALEGVRYIADHLRAEDEDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTIG 509

  Fly   498 ILM 500
            :.:
Zfish   510 LFL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	228/521 (44%)
		Neur_chan_LBD	28..236	CDD:280998	103/207 (50%)
		Neur_chan_memb	243..498	CDD:280999	114/277 (41%)
chrna2a	NP_001035417.1	LIC	9..513	CDD:273305	228/523 (44%)
		Neur_chan_LBD	37..243	CDD:280998	103/207 (50%)
		Neur_chan_memb	250..511	CDD:280999	115/278 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820