Protein Alignment nAChRbeta1 and Chrna9

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_075219.2
• Gene: Chrna9 / 65024
• RGDID: 621534
• Length: 479
• Species: Rattus norvegicus
• Alignment Length: 477
• Identity: 169/477 - (35%)
• Similarity: 271/477 - (56%)
• Gaps: 33/477 - (6%)

  Fly    29 ERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDE 93
            ::|..|||..|:..:|||::....:.|...:...|:.:::|:|||:.:.:|:|..|:|..|.||.
  Rat    32 QKLFSDLFEDYSSALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDR 96

  Fly    94 ADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTY 158
            ..|..:..:|:|.|.||:|||||:|.||........:||::...|.:.|..|||.:|||.:||||
  Rat    97 DQYDRLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTY 161

  Fly   159 FPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPT 222
            ||||.|.|.:.|||||:||:||.  ::|..:..||||:.:...|::..:||..||.. |..:.|
  Rat   162 FPFDSQQCNLTFGSWTYNGNQVD--IFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEP- 223

  Fly   223 ETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSK 287
            ..|:||.::::|::.||.|||::|.||||||..|.|||||.:||||:||::|||::.||.|:|::
  Rat   224 YPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAE 288

  Fly   288 ILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMK 352
            |:|.:..| |||.||.:.|..:.|.|..:|::::|.:|.|.....:|.:.:.:.|.|:...||:.
  Rat   289 IMPASENV-PLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWAKVVILKYMSRILFVY 352

  Fly   353 RPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGK--QSKMEVMELSDLHHPNCKINR 415
            ...::.|          .|.|        ::.|:.::.:..|  :|.::.....||...  |..|
  Rat   353 DVGESCL----------SPRH--------SQEPEQVTKVYSKLPESNLKTSRNKDLSRK--KEVR 397

  Fly   416 KVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVID 480
            |:.. .:||...|.   .:::||.....||  .|:.:|:||:.|::.........:||.||.|||
  Rat   398 KLLK-NDLGYQGGI---PQNTDSYCARYEA--LTKNIEYIAKCLKDHKATNSKGSEWKKVAKVID 456

  Fly   481 RLQLYIFFIVTTAGTVGILMDA 502
            |..::|||.:....||.|:..|
  Rat   457 RFFMWIFFAMVFVMTVLIIARA 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	168/473 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	80/207 (39%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)
Chrna9	NP_075219.2	LIC	8..474	CDD:455710	167/471 (35%)
		LGIC_ECD_nAChR_A9	31..237	CDD:349823	80/207 (39%)
		Cys-loop	155..169	CDD:349823	10/13 (77%)