Protein Alignment nAChRbeta1 and Chrna10

DIOPT Version :10

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_006229953.1
• Gene: Chrna10 / 64574
• RGDID: 620142
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 474
• Identity: 160/474 - (33%)
• Similarity: 238/474 - (50%)
• Gaps: 60/474 - (12%)

  Fly    30 RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEA 94
            :|.||||..|...:|||.:..|.:.|...:...|:|:::|:||::...:|:|..|.|..|.||..
  Rat    77 KLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPK 141

  Fly    95 DYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYF 159
            .||.:..:|:|...||:|||||:|.||........:||::...|.|.|..|||.:|||.:||:.|
  Rat   142 AYGDLDAIRIPSRLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAF 206

  Fly   160 PFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE-GDSNHPTE 223
            |||.|.|.:.|||||..|.|:.:......  ..|:|:.::..|.::.:||...|.. |..:.| .
  Rat   207 PFDAQRCGLTFGSWTHGGHQLDVRPRGTS--ASLADFVENVEWRVLGMPARRRVLTYGCCSEP-Y 268

  Fly   224 TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKI 288
            .|:||.:::||:...|..||:||.|.||.|..|.|:|||::||||:||:::||:|.||.|::::.
  Rat   269 PDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLILAES 333

  Fly   289 LPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKR 353
            :||...| |||.||.:.|..|.|.|..:|::|:|.::.||..|.:|.:.|.:.|.:|...|.
  Rat   334 MPPAESV-PLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPAWARVLLLGHLAKGLC--- 394

  Fly   354 PRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVN 418
                 :|...|..|.|.|....||...|...|                 ....|.|.|.
  Rat   395 -----VRERGEPCGQSKPLESAPSLQPPPASP-----------------AGPCHEPRCL------ 431

  Fly   419 SGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQ 483
                      |.:|:      ||...||        ||...|:.....:..||||.:|.|:||..
  Rat   432 ----------CHQEA------LLHHIAS--------IASTFRSHRAAQRRHEDWKRLARVMDRFF 472

  Fly   484 LYIFFIVTTAGTVGILMDA 502
            |.|||.:....::.:|:.|
  Rat   473 LGIFFCMALVMSLIVLVQA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	158/470 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	76/206 (37%)
		Cys-loop	152..166	CDD:349833	8/13 (62%)
Chrna10	XP_006229953.1	LIC	60..476	CDD:455710	155/457 (34%)
		LGIC_ECD	75..281	CDD:475126	76/206 (37%)