Protein Alignment nAChRbeta1 and lgc-24

DIOPT Version :9

• Sequence 1: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_001123110.2
• Gene: lgc-24 / 6418837
• WormBaseID: WBGene00045385
• Length: 389
• Species: Caenorhabditis elegans
• Alignment Length: 346
• Identity: 79/346 - (22%)
• Similarity: 132/346 - (38%)
• Gaps: 68/346 - (19%)

  Fly    13 ILVLVAFSLVSASEDEE------RLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71
            :||:....:||..|..:      :|..|||:.||..:...:....:......:.|:..|  ::.:
 Worm     7 VLVIHIHLVVSQWETGKSFTVLTKLRSDLFKNYNGSMPVGKGEYLEATPSLEVGFIHFI--DDDH 69

  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKV---------WKPDIVLFNNADGNYEVR 127
            ..|...:...|.|.|.:|:|:.|:|.|:   |...:|.         |.| ||.:.    :|:.|
 Worm    70 GFMSVVINAELTWIDERLKWNPANYSGV---REIVEKTFEFRKDNNCWMP-IVKYR----SYDRR 126

  Fly   128 YK---------SNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTC-IMKFGSWTFNGDQ--- 179
            |.         :..||...||:......:..:.|......:|.|.|.| ||...:.  |.|:
 Worm   127 YSELDLLEFSDARTLISYKGEIKTALQTMVTTKCQFSFGEYPNDYQNCSIMLIPNQ--NADEFRF 189

  Fly   180 VSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGDSN------------HPTETDITFYIII 232
            ||...|.|..|.:| ::......|:..:....|::...:|            :..:|:..|.::.
 Worm   190 VSPNGYCNPKFENL-EHRAVRVHDLHLMGVESNIFYTFANTYFTAEEVTGFEYMAKTEFRFNLMF 253

  Fly   233 RRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFL------LLVSKILPP 291
            :|......|.|.:|::|||...::....|.        |.||......|.      |.||||||.
 Worm   254 KRVNKLLNVKLSIPSILISMFLIIAGLFPN--------GYSIFGYAYCFFVEVMHGLYVSKILPN 310

  Fly   292 TSLVLPLIAKYLLFTFIMNTV 312
            ....:|.... |...|::.||
 Worm   311 DIRGIPYHGA-LALCFLIETV 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	79/346 (23%)
		Neur_chan_LBD	28..236	CDD:280998	51/247 (21%)
		Neur_chan_memb	243..498	CDD:280999	22/76 (29%)
lgc-24	NP_001123110.2	LGIC_ECD	62..226	CDD:355788	40/176 (23%)
		Cys-loop	160..174	CDD:349787	4/13 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810