DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta1 and Htr3b

DIOPT Version :9

Sequence 1:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_071525.1	Gene:	Htr3b / 58963	RGDID:	61820	Length:	437	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	81/342 - (23%)
Similarity:	163/342 - (47%)	Gaps:	17/342 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLCSILVLVAFSLVSASEDE------ERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINV 67
            ||.|.|::....::..:..:      .||.|.|.:.|:|.:|||.|..:...|...|....:::|
  Rat     3 LLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLCVHAVLDV 67

  Fly    68 NEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVL--FNNADGNYEVRYKS 130
            :.:||.:|:::|.|.||.|..|.|:.:.:..|..:.||...:|.|||::  |.:.:.:.::.|
  Rat    68 DVQNQKLKTSMWYREVWNDEFLSWNSSLFDDIQEISLPLSAIWAPDIIINEFVDVERSPDLPY-- 130

  Fly   131 NVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFV--DL 193
             |.:..:|.:....|....|:|::....||||.|.|.:.|.|.....:.:.|....|:..:  |.
  Rat   131 -VYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDIDLGFLRNQEDIENDK 194

  Fly   194 SDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVF 258
            ..:.....|.::.|.:..::.:..:....:  |.|.::|||..|.|.|:|::|::.:..:.:..|
  Rat   195 RSFLNDSEWQLLSVTSTYHIRQSSAGDFAQ--IRFNVVIRRCPLAYVVSLLIPSIFLMLVDLGSF 257

  Fly   259 YLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINW 323
            |||.....::....::|:...||.:.:|..:|.::....||..:......:..:|:..::::|.:
  Rat   258 YLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTSLIGVFFTVCMALLVLSLSKSILLIKF 322

  Fly   324 NF--RGPRTHRMPMYIR 338
            .:  |.....|..|.:|
  Rat   323 LYEERHSEQERPLMCLR 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	81/342 (24%)
		Neur_chan_LBD	28..236	CDD:280998	55/217 (25%)
		Neur_chan_memb	243..498	CDD:280999	19/98 (19%)
Htr3b	NP_071525.1	LIC	30..431	CDD:273305	77/315 (24%)
		Neur_chan_LBD	30..233	CDD:280998	53/207 (26%)
		Neur_chan_memb	242..>313	CDD:280999	13/70 (19%)
		HA-stretch	377..409
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810